The effect of hyaluronic acid hydrogels on dental pulp stem cells behavior

被引：71

作者：

Ahmadian, Elham ^{[1
,2
]}

Eftekhari, Aziz ^{[3
]}

Dizaj, Solmaz Maleki ^{[1
]}

Sharifi, Simin ^{[1
]}

Mokhtarpour, Masumeh ^{[4
]}

Nasibova, Aygun N. ^{[5
,6
]}

Khalilov, Rovshan ^{[5
,6
,7
,8
]}

Samiei, Mohammad ^{[1
,9
]}

机构：

[1] Tabriz Univ Med Sci, Dent & Periodontal Res Ctr, Tabriz, Iran

[2] Tabriz Univ Med Sci, Students Res Comm, Tabriz, Iran

[3] Maragheh Univ Med Sci, Pharmacol & Toxicol Dept, Maragheh, Iran

[4] Tabriz Univ, Dept Phys Chem, Tabriz, Iran

[5] Baku State Univ, Dept Biophys & Mol Biol, Baku, Azerbaijan

[6] Natl Acad Sci Azerbaijan, Inst Radiat Problems, Baku, Azerbaijan

[7] Joint Ukraine Azerbaijan Int Res & Educ Ctr Nanob, Drogobych, Ukraine

[8] Joint Ukraine Azerbaijan Int Res & Educ Ctr Nanob, Baku, Azerbaijan

[9] Tabriz Univ Med Sci, Fac Dent, Tabriz, Iran

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2019年 / 140卷

关键词：

Hyaluronic acid; Hydrogel; Dental pulp stem cell; SYNTHETIC EXTRACELLULAR-MATRIX; MECHANICAL-PROPERTIES; TISSUE; THERAPY; SCAFFOLD; DIFFERENTIATION; REGENERATION; GELATIN; PROLIFERATION; ANGIOGENESIS;

D O I：

10.1016/j.ijbiomac.2019.08.119

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dental caries and trauma, particularly in childhood, are among the most prevalent teeth problems, which result in the creation of cavities and probably tooth loss. Thus, novel regenerative approaches with high efficiency and less toxicity are required. Stem cell therapy along with the implementation of scaffolds has provided excellent opportunities in the regeneration of teeth structure. Hyaluronic acid (HA) hydrogels have enticed great attention in the field of regenerative medicine. The unique chemical and structural properties of HA and its derivatives have enabled their application in tissue engineering. Several factors such as the location and type of the lesion, teeth age, the type of capping materials determine the success rate of pulp therapy. HA hydrogels have been considered as biocompatible and safe scaffold supports in human dental cell therapies. (C) 2019 Elsevier B.V. All rights reserved.

引用

页码：245 / 254

页数：10

共 104 条

[1] Tailoring Mechanical Properties of Collagen-Based Scaffolds for Vascular Tissue Engineering: The Effects of pH, Temperature and Ionic Strength on Gelation [J].