Understanding the mechanism of radiation induced fibrosis and therapy options

被引：49

作者：

Ejaz, Asim ^{[1
]}

Greenberger, Joel S. ^{[2
]}

Rubin, Peter J. ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Plast Surg, Pittsburgh, PA USA

[2] Univ Pittsburgh, Dept Radiat Oncol, Canc Inst, Pittsburgh, PA USA

来源：

PHARMACOLOGY & THERAPEUTICS | 2019年 / 204卷

关键词：

Adipose derived stem cells; Radiation; Fibrosis; Skin; Transforming growth factor; Hepatocyte growth factor; GROWTH-FACTOR-BETA; MESENCHYMAL STEM-CELLS; HUMAN ADIPOSE-TISSUE; HUMAN DERMAL FIBROBLASTS; SMOOTH MUSCLE ACTIN; SMALL GTPASE DIRAS3; LATENT-TGF-BETA; IONIZING-RADIATION; BONE-MARROW; TRANSFORMING GROWTH-FACTOR-BETA-1;

D O I：

10.1016/j.pharmthera.2019.107399

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Radiation therapy has been increasingly employed as a tool to cure and palliate majority of solid tumors. Although radiotherapy has shown promising results in preserving structure and function of organs, it is associated with late side effects mainly manifested in the form of tissue fibrosis. Recent advances in molecular biology techniques has helped better understand the molecular mechanisms involved in radiation induced fibrosis. Currently, very few treatment modalities are available to treat the condition with moderate success rate. Stem cell therapies and particularly adipose tissue and adipose derived stem cells therapies have shown promising results in clinical applications. Identification of the key factors involved in the mitigation process will help to enhance the beneficial effects and develop new therapy approaches. (C) 2019 Published by Elsevier Inc.

引用

页数：14

共 237 条

[1] New developments in fibroblast and myofibroblast biology: Implications for fibrosis and scleroderma [J].