Gut microbiota, metabolites and host immunity

被引：2438

作者：

Rooks, Michelle G. ^{[1
]}

Garrett, Wendy S. ^{[1
,2
,3
,4
]}

机构：

[1] Harvard Univ, TH Chan Sch Publ Hlth, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

[3] Broad Inst Harvard & Massachusetts Inst Technol, Cambridge, MA 02142 USA

[4] Dana Farber Canc Inst, Boston, MA 02215 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2016年 / 16卷 / 06期

关键词：

CHAIN FATTY-ACIDS; ARYL-HYDROCARBON RECEPTOR; STAPHYLOCOCCUS-AUREUS; INTESTINAL MICROBIOTA; INFLAMMATORY RESPONSES; BACTERIAL STRAINS; GENE-EXPRESSION; HYBRID CAPTURE; GOBLET CELLS; T-CELLS;

D O I：

10.1038/nri.2016.42

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The microbiota - the collection of microorganisms that live within and on all mammals - provides crucial signals for the development and function of the immune system. Increased availability of technologies that profile microbial communities is facilitating the entry of many immunologists into the evolving field of host-microbiota studies. The microbial communities, their metabolites and components are not only necessary for immune homeostasis, they also influence the susceptibility of the host to many immune-mediated diseases and disorders. In this Review, we discuss technological and computational approaches for investigating the microbiome, as well as recent advances in our understanding of host immunity and microbial mutualism with a focus on specific microbial metabolites, bacterial components and the immune system.

引用

页码：341 / 352

页数：12

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