Plasma levels of soluble amyloid precursor protein β in symptomatic Alzheimer's disease

被引：6

作者：

Alexopoulos, Panagiotis ^{[1
,2
]}

Gleixner, Lena-Sophie ^{[1
]}

Werle, Lukas ^{[1
,3
]}

Buhl, Felix ^{[1
]}

Thierjung, Nathalie ^{[1
]}

Giourou, Evangelia ^{[2
]}

Kagerbauer, Simone M. ^{[4
]}

Gourzis, Philippos ^{[2
]}

Kuebler, Hubert ^{[5
]}

Grimmer, Timo ^{[1
]}

Yakushev, Igor ^{[6
]}

Martin, Jan ^{[4
]}

Kurz, Alexander ^{[1
]}

Perneczky, Robert ^{[7
,8
,9
,10
]}

机构：

[1] Tech Univ Munich, Dept Psychiat & Psychotherapy, Klinikum Rechts Isar, Munich, Germany

[2] Univ Patras, Dept Psychiat, Univ Hosp Rion, Patras 26500, Greece

[3] Max Planck Inst Psychiat, Munich, Germany

[4] Tech Univ Munich, Dept Anaesthesiol, Klinikum Rechts Isar, Munich, Germany

[5] Tech Univ Munich, Dept Urol, Klinikum Rechts Isar, Munich, Germany

[6] Tech Univ Munich, Dept Nucl Med, Klinikum Rechts Isar, Munich, Germany

[7] Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Munich, Germany

[8] Imperial Coll Sci Technol & Med, Sch Publ Hlth, Neuroepidemiol & Ageing Res Unit, Fac Med, London, England

[9] West London Mental Hlth NHS Trust, London, England

[10] German Ctr Neurodegenerat Dis DZNE Munich, Munich, Germany

来源：

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | 2018年 / 268卷 / 05期

关键词：

Soluble amyloid precursor protein beta (sAPP beta); Biomarker-underpinned diagnoses; FDG-PET; Upstream biomarkers; Mild cognitive impairment; Dementia due to Alzheimer's disease; MILD COGNITIVE IMPAIRMENT; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; BIOMARKERS; DEMENTIA; RECOMMENDATIONS; TAU; CSF; DECREASE;

D O I：

10.1007/s00406-017-0815-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The established biomarkers of Alzheimer's disease (AD) require invasive endeavours or presuppose sophisticated technical equipment. Consequently, new biomarkers are needed. Here, we report that plasma levels of soluble amyloid precursor protein beta (sAPP beta), a protein of the initial phase of the amyloid cascade, were significantly lower in patients with symptomatic AD (21 with mild cognitive impairment due to AD and 44 with AD dementia) with AD-typical cerebral hypometabolic pattern compared with 27 cognitively healthy elderly individuals without preclinical AD. These findings yield further evidence for the potential of sAPP beta in plasma as an AD biomarker candidate.

引用

页码：519 / 524

页数：6

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