Effect of a miso diet on colonic aberrant crypt foci in F344 rats exposed to azoxymethane

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作者：
Masaoka, Y
Watanabe, H
Tanizaki, M
Ando, Y
Yamada, K
Gotoh, T
Fijimoto, N
Ito, A
机构：
来源：
RECENT ADVANCES IN GASTROENTEROLOGICAL CARCINOGENESIS I | 1996年
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R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Modifying effect of dietary exposure to mise diet on the developement of colonic aberrant crypt foci(ACF) induced by azoxymethane(AOM) were investigated in 6 week old male F344 rats. The total number of ACF/colon in the mise diet groups was decreased in a dose dependent manner. In groups given 10% and 20% mise, the frequences of ACF/colon were significantly lower than that of AOM alone (P<0.05 and P<0.01). Since biochainin A is known to relate the cell cycle regulation, the mise diet containing biochainin A might be a possible dietary-preventive agent for rat colon carcinogenesis.
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页码：1181 / 1185
页数：5
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