Targeted Isolation of Saalfelduracin B-D from Amycolatopsis saalfeldensis Using LC-MS/MS-Based Molecular Networking

被引：7

作者：

Um, Soohyun ^{[1
]}

Seibel, Elena ^{[1
]}

Schalk, Felix ^{[1
]}

Balluff, Sven ^{[1
]}

Beemelmanns, Christine ^{[1
]}

机构：

[1] Leibniz Inst Nat Prod Res & Infect Biol, Hans Knoll Inst, D-07745 Jena, Germany

来源：

JOURNAL OF NATURAL PRODUCTS | 2021年 / 84卷 / 04期

关键词：

NATURAL-PRODUCTS; MASS-SPECTROMETRY; DISCOVERY;

D O I：

10.1021/acs.jnatprod.0c01027

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

High-resolution tandem mass spectrometry (HR-MS2)-based metabolomic studies of Amycolatopsis saalfeldensis, isolated from the "Saalfelder Feengrotten" caves in Germany, led to the isolation of three ribosomally synthesized and post-translationally modified type II thiopeptides, saalfelduracin B-D (1-3) and the known saalfelduracin A (4). The structures of all four compounds were determined by comparative two-dimensional NMR analysis and high-resolution tandem mass spectrometry.

引用

页码：1002 / 1011

页数：10

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