Degradation Behavior of Hydrogel Based on Cross linked Poly(aspartic acid)

被引：20
|
作者：
Yang, Jun [1 ]
Wang, Fang [1 ]
Tan, Tianwei [1 ]
机构：
[1] Beijing Univ Chem Technol, Beijing Key Lab Bioproc, Beijing 100029, Peoples R China
来源：
JOURNAL OF APPLIED POLYMER SCIENCE | 2010年 / 117卷 / 01期
基金：
国家高技术研究发展计划(863计划); 美国国家科学基金会;
关键词：
crosslinking density; degradation; hydrogel; poly(aspartic acid); ENZYMATIC DEGRADATION; MICROBIAL-DEGRADATION; SPHINGOMONAS SP; NETWORKS; RHEOLOGY; POLYMER;
D O I：
10.1002/app.31943
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The degradation behavior of hydrogel based on poly(aspartic acid) (PASP) which crosslinked by 1, 6-hexamethylene diamine (HD) was studied in alpha-chymotrypsin solution. The degradation behaviors of PASP under different crosslinking levels were evaluated as a function of biodegradation time by monitoring the changes of crosslinking density, molecular weight, rheological behavior, interior morphology, mass loss, and swelling ratio. It was found that the degradation behaviors relied heavily on the crosslinking density which calculated from the Flory-Rehner equation. A pseudo first-kinetic equation was proposed to model the mass loss behavior and the degradation rate constant was calculated under different crosslinking levels. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 117: 178-185, 2010
引用
收藏
页码：178 / 185
页数：8
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