The zebrafish Pax3 and Pax7 homologues are highly conserved, encode multiple isoforms and show dynamic segment-like expression in the developing brain

被引：111

作者：

Seo, HC ^{[1
]}

Sætre, BO ^{[1
]}

Håvik, B ^{[1
]}

Ellingsen, S ^{[1
]}

Fjose, A ^{[1
]}

机构：

[1] Univ Bergen, Dept Mol Biol, N-5020 Bergen, Norway

来源：

MECHANISMS OF DEVELOPMENT | 1998年 / 70卷 / 1-2期

关键词：

alternative splicing; hindbrain segmentation; homeodomain; paired domain;

D O I：

10.1016/S0925-4773(97)00175-5

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This study describes the isolation and characterization of zebrafish homologues of the mammalian Pax3 and Pax7 genes. The proteins encoded by both zebrafish genes are highly conserved (>83%) relative to the known mammalian sequences. Also the neural expression patterns during embryogenesis are very similar to the murine homologues. However, observed differences in neural crest and mesodermal expression relative to mammals could reflect some functional divergence in the development of these tissues. For the zebrafish Pax7 protein we report the first full-length amino acid sequences in vertebrates and show the existence of three additional isoforms which have truncations in the homeodomain and/or the C-terminal region. These novel variants provide evidence for additional isoform diversity of vertebrate Pax proteins. (C) 1998 Elsevier Science Ireland Ltd.

引用

页码：49 / 63

页数：15

共 53 条

[1] Developmental biology - The brain organization [J].