Short-Chain Fatty Acids in Chronic Kidney Disease: Focus on Inflammation and Oxidative Stress Regulation

被引：57
作者：
Magliocca, Giorgia [1 ,2 ]
Mone, Pasquale [3 ,4 ,5 ]
Di Iorio, Biagio Raffaele [6 ]
Heidland, August [7 ,8 ]
Marzocco, Stefania [1 ]
机构：
[1] Univ Salerno, Dept Pharm, I-84084 Fisciano, Italy
[2] Univ Salerno, PhD Program Drug Discovery & Dev, I-84084 Fisciano, Italy
[3] Albert Einstein Coll Med, Dept Med, Div Cardiol, 1300 Morris Pk Ave, New York, NY 10461 USA
[4] ASL Avellino, I-83100 Avellino, Italy
[5] Univ Campania Luigi Vanvitelli, Dept Mental & Phys Hlth & Prevent Med, I-80138 Naples, Italy
[6] UOC Nephrol AORN San Giuseppe Moscati, I-83100 Avellino, Italy
[7] Univ Wurzburg, KfH Kidney Ctr Wurzburg, Dept Internal Med, D-97080 Wurzburg, Germany
[8] Univ Wurzburg, KfH Kidney Ctr Wurzburg, KfH Kidney Ctr, D-97080 Wurzburg, Germany
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 10期
关键词：
chronic kidney disease; short-chain fatty acids; oxidative stress; inflammation; uremic toxins; PROTEIN-COUPLED RECEPTOR; INTESTINAL EPITHELIAL-CELLS; NF-KAPPA-B; GUT MICROBIOTA; UREMIC TOXINS; SIGNALING PATHWAY; INDOXYL SULFATE; METABOLITE BUTYRATE; NERVOUS-SYSTEM; BLOOD-PRESSURE;
D O I：
10.3390/ijms23105354
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chronic Kidney Disease (CKD) is a debilitating disease associated with several secondary complications that increase comorbidity and mortality. In patients with CKD, there is a significant qualitative and quantitative alteration in the gut microbiota, which, consequently, also leads to reduced production of beneficial bacterial metabolites, such as short-chain fatty acids. Evidence supports the beneficial effects of short-chain fatty acids in modulating inflammation and oxidative stress, which are implicated in CKD pathogenesis and progression. Therefore, this review will provide an overview of the current knowledge, based on pre-clinical and clinical evidence, on the effect of SCFAs on CKD-associated inflammation and oxidative stress.
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页数：24
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