Dyslipidemia and Cardiovascular Risk in Human Immunodeficiency Virus Infection

被引：34
作者：
Kelesidis, Theodoros [1 ]
Currier, Judith S. [1 ]
机构：
[1] Univ Calif Los Angeles, Dept Med, David Geffen Sch Med, Div Infect Dis, Los Angeles, CA 90035 USA
来源：
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2014年 / 43卷 / 03期
关键词：
Dyslipidemia; Cardiovascular risk; Human immunodeficiency virus; Antiretroviral therapy; HIGH-DENSITY-LIPOPROTEIN; REVERSE-TRANSCRIPTASE INHIBITORS; INDIVIDUAL ANTIRETROVIRAL DRUGS; BOOSTED PROTEASE INHIBITORS; TREATMENT-NAIVE; MYOCARDIAL-INFARCTION; HIV-1-INFECTED PATIENTS; HIV-INFECTION; DOUBLE-BLIND; INITIAL TREATMENT;
D O I：
10.1016/j.ecl.2014.06.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The pathogenesis of atherosclerosis in human immunodeficiency virus (HIV)-infected individuals is incompletely understood and appears to be multifactorial. Proatherogenic changes in blood and tissue lipids are associated with an increased risk of cardiovascular disease among HIV-infected subjects, and these changes may be both quantitative (dyslipidemia) and qualitative. In view of the pivotal role of dyslipidemia in the process of atherosclerosis, the increased incidence of dyslipidemia in HIV-infected individuals, and the emerging role of lipid abnormalities in systemic pathophysiologic processes such as immune activation, we review the contributions of dyslipidemia to cardiovascular risk in HIV infection.
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页码：665 / +
页数：21
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