One-Pot Three-Component Synthesis of 3-Aminoalkyl Indoles Catalyzed by Molecular Iodine

被引：9
作者：
Depa, Navaneetha [2 ]
Erothu, Harikrishna [1 ,2 ]
机构：
[1] KLEF, Dept Chem, CAES, Guntur 522502, Andhra Pradesh, India
[2] KLEF, Dept Chem, Guntur 522502, Andhra Pradesh, India
来源：
CHEMISTRYSELECT | 2019年 / 4卷 / 33期
关键词：
3-aminoalkyl indole; aniline; ethanol; iodine; one-pot three-component reaction; FRIEDEL-CRAFTS ALKYLATION; SOLVENT-FREE; MULTICOMPONENT SYNTHESIS; METAL-FREE; FACILE SYNTHESIS; DOMINO REACTION; EFFICIENT; DERIVATIVES; KETONES; ALCOHOLS;
D O I：
10.1002/slct.201902832
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A facile one-pot three-component coupling (3CC) of indoles, aldehydes, and N-alkyl anilines has been attained using a catalytic quantity of molecular iodine under neutral conditions to afford 3-aminoalkyl indoles at room temperature. The salient features of this method are the mild reaction conditions, the operational simplicity of the method, outstanding yields in moderately at short reaction times and low cost of the catalyst.
引用
收藏
页码：9722 / 9725
页数：4
相关论文
共 50 条
  • [41] Iodine catalyzed synthesis of the chromene derivatives in one-pot
    Zeng, Li Yan
    Lv, Mei Fang
    Cai, Chun
    CHINESE CHEMICAL LETTERS, 2012, 23 (12) : 1347 - 1351
  • [42] Iodine catalyzed one-pot five-component reactions for direct synthesis of densely functionalized piperidines
    Khan, Abu T.
    Khan, Md. Musawwer
    Bannuru, Kranthi K. R.
    TETRAHEDRON, 2010, 66 (39) : 7762 - 7772
  • [43] A Selective Three-Component, One-Pot Approach for the Synthesis of 1,2-Dihydroquinazolines and Quinazolines
    Dayakar, Cherupally
    Raju, BhimapakaChina
    CHEMISTRYSELECT, 2018, 3 (32): : 9388 - 9392
  • [44] Iodine-mediated one-pot synthesis of indoles and 3-dimethylaminoindoles via annulation of enaminones
    Jerezano, Alberto V.
    Labarrios, Ehecatl M.
    Jimenez, Fabiola E.
    del Carmen Cruz, Maria
    Pazos, Diana C.
    Gutierrez, Rsuini U.
    Delgado, Francisco
    Tamariz, Joaquin
    ARKIVOC, 2014, : 18 - 53
  • [45] Piperidine-Iodine as Efficient Dual Catalyst for the One-Pot, Three-Component Synthesis of Coumarin-3-Carboxamides
    Velasco, Manuel
    Romero-Ceronio, Nancy
    Torralba, Rosalia
    Abreu, Oswaldo Hernandez
    Vilchis-Reyes, Miguel A.
    Alarcon-Matus, Erika
    Ramos-Rivera, Erika M.
    Aparicio, David M.
    Jimenez, Jacqueline
    Garcia, Eric Aguilar
    Cruz Cruz, David
    Villegas Gomez, Clarisa
    Alvarado, Cuauhtemoc
    MOLECULES, 2022, 27 (14):
  • [46] Iodine-catalyzed three-component one-pot synthesis of novel 1,8-dioxo-decahydroacridines derivatives bearing benzene sulfonamide moiety
    Li, Shenghui
    Ding, Shan
    Xu, Shengjie
    Zhang, Jinchao
    Wang, Shuxiang
    Zhou, Chuanqi
    Li, Xiaoliu
    RESEARCH ON CHEMICAL INTERMEDIATES, 2014, 40 (05) : 2091 - 2102
  • [47] A one-pot, three-component synthesis of thiazolidine-2-thiones
    Ziyaei-Halimehjani, Azim
    Marjani, Katayoun
    Ashouri, Akram
    TETRAHEDRON LETTERS, 2012, 53 (27) : 3490 - 3492
  • [48] One-pot, three-component synthesis of pyranocoumarins containing an aroyl group
    Khodabakhshi, Saeed
    Jafari, Fariba
    Marahel, Farzaneh
    Baghernejad, Mojtaba
    HETEROCYCLIC COMMUNICATIONS, 2014, 20 (05) : 285 - 288
  • [49] One-Pot, Three-Component Assembly of Indoloquinolines: Total Synthesis of Isocryptolepine
    Aksenov, Alexander V.
    Aksenov, Dmitrii A.
    Orazova, Naila A.
    Aksenov, Nicolai A.
    Griaznov, Georgii D.
    De Carvalho, Annelise
    Kiss, Robert
    Mathieu, Veronique
    Kornienko, Alexander
    Rubin, Michael
    JOURNAL OF ORGANIC CHEMISTRY, 2017, 82 (06) : 3011 - 3018
  • [50] Efficient three-component one-pot synthesis of steroidal polysubstituted anilines
    Zhang, Yan-Ling
    Li, Ya-Fei
    Shi, Yun-Kai
    Yu, Bin
    Zhang, Guo-Chen
    Qi, Ping-Ping
    Fu, Dong-Jun
    Shan, Li-Hong
    Liu, Hong-Min
    STEROIDS, 2015, 104 : 1 - 7
12345