Parvovirus B19-associated graft failure after allogeneic hematopoietic stem cell transplantation

被引：6
|
作者：
Rattani, Nabila [1 ]
Matheny, Christina [1 ]
Eckrich, Michael J. [1 ]
Madden, Lisa M. [1 ]
Quigg, Troy C. [1 ,2 ]
机构：
[1] Methodist Childrens Hosp, Texas Transplant Inst, Pediat Blood & Marrow Transplantat Program, San Antonio, TX USA
[2] Helen DeVos Childrens Hosp, Pediat Blood & Marrow Transplantat Program, 10th Floor MC185,100 Michigan St NE, Grand Rapids, MI 49503 USA
来源：
CANCER REPORTS | 2022年 / 5卷 / 01期
关键词：
allogeneic hematopoietic stem cell transplantation; graft failure; parvovirus B19 infection;
D O I：
10.1002/cnr2.1403
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background Parvovirus B19 (PVB19) infection has been implicated in allograft failure or dysfunction in solid organ transplantation (SOT) and allogeneic hematopoietic stem cell transplantation (allo-HSCT), but the literature is limited. Case Two pediatric patients were diagnosed with PVB19 infection around the time of allo-HSCT graft failure. Both cases were secondary graft failure and required second allo-HSCT. Conclusion There are many risk factors and potential confounders in determining the exact etiology of graft failure after allo-HSCT. These two cases highlight the importance of including PVB19 in the diagnostic evaluation for graft failure. PVB19 infection may be an important risk factor for allo-HSCT graft failure.
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页数：5
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