Inflammation 2010: New Adventures of an Old Flame

被引：1257
作者：
Medzhitov, Ruslan [1 ,2 ]
机构：
[1] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
[2] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA
来源：
CELL | 2010年 / 140卷 / 06期
关键词：
DISEASE;
D O I：
10.1016/j.cell.2010.03.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Inflammation is an essential immune response that enables survival during infection or injury and maintains tissue homeostasis under a variety of noxious conditions. Inflammation comes at the cost of a transient decline in tissue function, which can in turn contribute to the pathogenesis of diseases of altered homeostasis.
引用
收藏
页码：771 / 776
页数：6
相关论文
共 15 条
  • [1] Cellular and Molecular Mechanisms of Pain
    Basbaum, Allan I.
    Bautista, Diana M.
    Scherrer, Gregory
    Julius, David
    [J]. CELL, 2009, 139 (02) : 267 - 284
  • [2] Besedovsky HO, 2000, Z RHEUMATOL, V59, P26, DOI 10.1007/s003930070014
  • [3] Living with the past: Evolution, development, and patterns of disease
    Gluckman, PD
    Hanson, MA
    [J]. SCIENCE, 2004, 305 (5691) : 1733 - 1736
  • [4] Inflammation and metabolic disorders
    Hotamisligil, Goekhan S.
    [J]. NATURE, 2006, 444 (7121) : 860 - 867
  • [5] Majno G., 2004, CELLS TISSUES DIS, V2nd
  • [6] Majno G., 1975, The healing hand: Man and wound in the ancient world
  • [7] Origin and physiological roles of inflammation
    Medzhitov, Ruslan
    [J]. NATURE, 2008, 454 (7203) : 428 - 435
  • [8] Points of control in inflammation
    Nathan, C
    [J]. NATURE, 2002, 420 (6917) : 846 - 852
  • [9] Prostaglandins and sickness behavior: Old story, new insights
    Pecchi, Emilie
    Dallaporta, Michel
    Jean, Andre
    Thirion, Sylvie
    Troadec, Jean-Denis
    [J]. PHYSIOLOGY & BEHAVIOR, 2009, 97 (3-4) : 279 - 292
  • [10] Trophic macrophages in development and disease
    Pollard, Jeffrey W.
    [J]. NATURE REVIEWS IMMUNOLOGY, 2009, 9 (04) : 259 - 270
12