Focal Lesions of Human Hippocampal CA1 Neurons in Transient Global Amnesia Impair Place Memory

被引：132

作者：

Bartsch, T. ^{[1
]}

Schoenfeld, R. ^{[2
]}

Mueller, F. J. ^{[3
]}

Alfke, K. ^{[4
]}

Leplow, B. ^{[2
]}

Aldenhoff, J. ^{[3
]}

Deuschl, G. ^{[1
]}

Koch, J. M. ^{[3
]}

机构：

[1] Univ Kiel, Dept Neurol, Univ Hosp Schleswig Holstein, D-2300 Kiel, Germany

[2] Univ Halle Wittenberg, Inst Psychol, Halle, Germany

[3] Univ Kiel, Dept Psychiat, Univ Hosp Schleswig Holstein, D-2300 Kiel, Germany

[4] Univ Kiel, Inst Neuroradiol, Univ Hosp Schleswig Holstein, D-2300 Kiel, Germany

来源：

SCIENCE | 2010年 / 328卷 / 5984期

关键词：

SPATIAL MEMORY; RECOGNITION MEMORY; DAMAGE; RATS; REPRESENTATIONS; CLASSIFICATION; NAVIGATION; DEFICITS; SYSTEM; SECTOR;

D O I：

10.1126/science.1188160

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A critical role in place learning has been attributed to place cells within the cornu ammonis 1 (CA1) sector of the hippocampus in rodents. The role of CA1 cells in the human hippocampus with regard to place learning remains elusive. Using a virtual Morris water maze, we investigated patients with acute transient global amnesia (TGA), a rare self-limiting dysfunction of the hippocampal system. Fourteen individuals with selective and focal lesions in the CA1 sector of the hippocampus showed a profound impairment in place learning. The size of the lesions and the duration of the TGA correlated with the deficit in the performance.

引用

页码：1412 / 1415

页数：4

共 33 条

[11] Hippocampal magnetic resonance imaging abnormalities in transient global amnesia [J].

Cianfoni, A ;

Tartaglione, T ;

Gaudino, S ;

Pilato, F ;

Saturno, E ;

Tonali, PA ;

Di Lazzaro, V .

ARCHIVES OF NEUROLOGY, 2005, 62 (09) :1468-1469

[12]

Clark RE, 2000, J NEUROSCI, V20, P8853

[13] The hippocampus, memory, and place cells: Is it spatial memory or a memory space? [J].

Eichenbaum, H ;

Dudchenko, P ;

Wood, E ;

Shapiro, M ;

Tanila, H .

NEURON, 1999, 23 (02) :209-226

[14] Parahippocampal and retrosplenial contributions to human spatial navigation [J].

Epstein, Russell A. .

TRENDS IN COGNITIVE SCIENCES, 2008, 12 (10) :388-396

[15] Spatial representations of hippocampal CA1 neurons are modulated by behavioral context in a hippocampus-dependent memory task [J].

Griffin, Amy L. ;

Eichenbaum, Howard ;

Hasselmo, Michael E. .

JOURNAL OF NEUROSCIENCE, 2007, 27 (09) :2416-2423

[16] The well-worn route and the path less traveled: Distinct neural bases of route following and wayfinding in humans [J].

Hartley, T ;

Maguire, EA ;

Spiers, HJ ;

Burgess, N .

NEURON, 2003, 37 (05) :877-888

[17] SYNDROMES OF TRANSIENT AMNESIA - TOWARDS A CLASSIFICATION - A STUDY OF 153 CASES [J].

HODGES, JR ;

WARLOW, CP .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1990, 53 (10) :834-843

[18]

Keefe J.O., 1978, HIPPOCAMPUS COGNITIV

[19] Hippocampal lesion prevents spatial relational learning in adult macaque monkeys [J].

Lavenex, PB ;

Amaral, DG ;

Lavenex, P .

JOURNAL OF NEUROSCIENCE, 2006, 26 (17) :4546-4558

[20] Diffusion-weighted imaging in transient global amnesia exposes the CA1 region of the hippocampus [J].

Lee, Ho Yun ;

Kim, Jae Hyoung ;

Weon, Young-Cheol ;

Lee, Jung Seok ;

Kim, Sang Yun ;

Youn, Sung Won ;

Kim, Sung Hyun .

NEURORADIOLOGY, 2007, 49 (06) :481-487

← 1 2 3 4 →