Focal Lesions of Human Hippocampal CA1 Neurons in Transient Global Amnesia Impair Place Memory

被引：132

作者：

Bartsch, T. ^{[1
]}

Schoenfeld, R. ^{[2
]}

Mueller, F. J. ^{[3
]}

Alfke, K. ^{[4
]}

Leplow, B. ^{[2
]}

Aldenhoff, J. ^{[3
]}

Deuschl, G. ^{[1
]}

Koch, J. M. ^{[3
]}

机构：

[1] Univ Kiel, Dept Neurol, Univ Hosp Schleswig Holstein, D-2300 Kiel, Germany

[2] Univ Halle Wittenberg, Inst Psychol, Halle, Germany

[3] Univ Kiel, Dept Psychiat, Univ Hosp Schleswig Holstein, D-2300 Kiel, Germany

[4] Univ Kiel, Inst Neuroradiol, Univ Hosp Schleswig Holstein, D-2300 Kiel, Germany

来源：

SCIENCE | 2010年 / 328卷 / 5984期

关键词：

SPATIAL MEMORY; RECOGNITION MEMORY; DAMAGE; RATS; REPRESENTATIONS; CLASSIFICATION; NAVIGATION; DEFICITS; SYSTEM; SECTOR;

D O I：

10.1126/science.1188160

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A critical role in place learning has been attributed to place cells within the cornu ammonis 1 (CA1) sector of the hippocampus in rodents. The role of CA1 cells in the human hippocampus with regard to place learning remains elusive. Using a virtual Morris water maze, we investigated patients with acute transient global amnesia (TGA), a rare self-limiting dysfunction of the hippocampal system. Fourteen individuals with selective and focal lesions in the CA1 sector of the hippocampus showed a profound impairment in place learning. The size of the lesions and the duration of the TGA correlated with the deficit in the performance.

引用

页码：1412 / 1415

页数：4

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