Crystal structure of the nucleosome core particle at 2.8 angstrom resolution

被引：6948

作者：

Luger, K ^{[1
]}

Mader, AW ^{[1
]}

Richmond, RK ^{[1
]}

Sargent, DF ^{[1
]}

Richmond, TJ ^{[1
]}

机构：

[1] ETH HONGGERBERG, ETHZ, INST MOL BIOL & BIOPHYS, CH-8093 ZURICH, SWITZERLAND

来源：

NATURE | 1997年 / 389卷 / 6648期

关键词：

D O I：

10.1038/38444

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The X-ray crystal structure of the nucleosome cave particle of chromatin shows in atomic detail how the histone protein octamer is assembled and how 146 base pairs of DNA are organized into a superhelix around it. Both histone/histone and histone/DNA interactions depend on the histone fold domains and additional, well ordered structure elements extending from this motif. Histone amino-terminal tails pass over and between the gyres of the DNA superhelix to contact neighbouring particles. The lack of uniformity between multiple histone/DNA-binding sites causes the DNA to deviate from ideal superhelix geometry.

引用

页码：251 / 260

页数：10