Photoreceptor Cell Injury Starts in the Initial Stage of Vogt-Koyanagi-Harada Disease

被引:5
作者
Zhu, Ruilin [1 ]
Zhang, Jing [1 ]
Qiao, Lijun [1 ]
Zhang, Yadi [1 ]
Gu, Xiaopeng [1 ]
Yang, Liu [1 ]
机构
[1] Peking Univ, Hosp 1, Key Lab Vis Loss & Restorat, Minist Educ,Dept Ophthalmol, Beijing, Peoples R China
基金
中国国家自然科学基金;
关键词
Fundus autofluorescence; optical coherence tomography; photoreceptor; photoreceptor injury; VKH disease; OPTICAL COHERENCE TOMOGRAPHY; FUNDUS AUTOFLUORESCENCE; EYES;
D O I
10.1080/09273948.2017.1285035
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: To demonstrate photoreceptor cell injury in Vogt-Koyanagi-Harada (VKH) disease.Methods: The SD-OCT and FAF tests of 16 patients diagnosed with VKH disease that was followed up from the initial stage to the convalescent stage were reviewed.Results: In the initial stage of VKH disease, there was hyperautofluerescence around the macular edema. In the convalescent stage of VKH disease, loss of photoreceptor and injury of RPE have been detected by OCT scan at the same area, which was corresponded with the abnormalities in FAF.Conclusions: The VKH disease causes photoreceptor injury starting in the initial stage of the disease.
引用
收藏
页码:934 / 942
页数:9
相关论文
共 18 条
[1]  
Bae SS, 2016, OCUL IMMUNOL INFLAMM, V22, P1
[2]   Vogt-Koyanagi-Harada disease: Novel insights into pathophysiology, diagnosis and treatment [J].
Du, Liping ;
Kijlstra, Aize ;
Yang, Peizeng .
PROGRESS IN RETINAL AND EYE RESEARCH, 2016, 52 :84-111
[3]   Increased Fundus Autofluorescence Related to Outer Retinal Disruption [J].
Freund, K. Bailey ;
Mrejen, Sarah ;
Jung, Jesse ;
Yannuzzi, Lawrence A. ;
Boon, Camiel J. F. .
JAMA OPHTHALMOLOGY, 2013, 131 (12) :1645-1649
[4]   Ultrastructural changes in rat eyes with experimental Vogt-Koyanagi-Harada disease [J].
Hayakawa, K ;
Ishikawa, M ;
Yamaki, K .
JAPANESE JOURNAL OF OPHTHALMOLOGY, 2004, 48 (03) :222-227
[5]   The role of enhanced depth imaging optical coherence tomography in chronic Vogt-Koyanagi-Harada disease [J].
Jap, Aliza ;
Chee, Soon-Phaik .
BRITISH JOURNAL OF OPHTHALMOLOGY, 2017, 101 (02) :186-189
[6]   Blue light and near-infrared fundus autofluorescence in acute Vogt-Koyanagi-Harada disease [J].
Koizumi, Hideki ;
Maruyama, Kazuichi ;
Kinoshita, Shigeru .
BRITISH JOURNAL OF OPHTHALMOLOGY, 2010, 94 (11) :1499-1505
[7]   Fundus autofluorescence as a marker of disease severity in Vogt-Koyanagi-Harada disease [J].
Morita, Celso ;
Sakata, Viviane Mayumi ;
Caso Rodriguez, Ever Ernesto ;
Abdallah, Smairah Frutuoso ;
Lavezzo, Marcelo Mendes ;
da Silva, Felipe T. ;
Machado, Cleide Guimaraes ;
Oyamada, Maria Kiyoko ;
Hirata, Carlos Eduardo ;
Yamamoto, Joyce Hisae .
ACTA OPHTHALMOLOGICA, 2016, 94 (08) :E820-E821
[8]   Clinical applications of spectral domain optical coherence tomography in retinal diseases [J].
Murthy, R. K. ;
Haji, Shamim ;
Sambhav, Kumar ;
Grover, Sandeep ;
Chalam, K. V. .
BIOMEDICAL JOURNAL, 2016, 39 (02) :107-120
[9]   Oxidative photoreceptor cell damage in autoimmune uveitis [J].
Nguyen A.M. ;
Rao N.A. .
Journal of Ophthalmic Inflammation and Infection, 2011, 1 (1) :7-13
[10]   Vogt-Koyanagi-Harada disease [J].
O'Keefe, Ghazala A. Datoo ;
Rao, Narsing A. .
SURVEY OF OPHTHALMOLOGY, 2017, 62 (01) :1-25