Design of chiral picen-based metal complexes for molecular recognition of α-aminoacids and nucleic acids

被引：66
作者：
Aldrich-Wright, JR
Vagg, RS
Williams, PA [1 ]
机构：
[1] Univ Western Sydney Nepean, Fac Sci & Technol, Nepean, ON 2747, Canada
[2] Univ Western Sydney Macarthur, Dept Chem, Macarthur, NSW 2560, Australia
[3] Macquarie Univ, Sch Chem, N Ryde, NSW 2109, Australia
来源：
COORDINATION CHEMISTRY REVIEWS | 1997年 / 166卷
关键词：
molecular recognition; chiral discrimination; noncovalent binding; molecular design; N-4-tetradentates; alpha-aminoacidates; asymmetric synthesis; DNA metallointercalators;
D O I：
10.1016/S0010-8545(97)00048-9
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Molecular design features which determine the enantio-and stereoselective behaviour of metal complexes derived from chiral linear N-4-tetradentate ligands with terminal alpha-pyridyl are described. Examples are provided of the ability of these complexes to recognise the molecular structures of biologically interesting molecules (alpha-aminoacids and nucleic acids). Noncovalent binding and steric factors which influence these molecular recognition processes are analysed and assessed. These include discriminatory interactions which occur at the intraligand, interligand (intramolecular) and intermolecular levels. (C) 1997 Elsevier Science S.A.
引用
收藏
页码：361 / 389
页数：29
相关论文
共 112 条
[41]   CHIRAL METAL-COMPLEXES .34. STEREOSPECIFIC CIS-ALPHA COORDINATION TO COBALT(III) BY THE NEW TETRADENTATE LIGAND N,N'-DIMETHYL-N,N'-DI(2-PICOLYL)-1,2-DIAMINOCYCLOHEXANE [J].
FENTON, RR ;
STEPHENS, FS ;
VAGG, RS ;
WILLIAMS, PA .
INORGANICA CHIMICA ACTA, 1991, 182 (01) :67-75
[42]   CHIRAL METAL-COMPLEXES .41. STEREOISOMERISM IN PALLADIUM(II) COMPLEXES OF A SERIES OF CHIRAL BIS-PICOLYL N-4-TETRADENTATE LIGANDS [J].
FENTON, RR ;
STEPHENS, FS ;
VAGG, RS ;
WILLIAMS, PA .
INORGANICA CHIMICA ACTA, 1995, 231 (1-2) :73-85
[43]   CHIRAL METAL-COMPLEXES .36. STEREOSELECTIVITY ENHANCED BY N,N'-DIMETHYLATION OF A CHIRAL N4 TETRADENTATE, INCLUDING THE CRYSTAL-STRUCTURE OF DELTA-ALPHA-1,ALPHA-2-([N,N'-DIMETHYL-3R-METHYL-1,6-DI(2-PYRIDYL)-2,5-DIAZAHEXANE)(S-ALANINATO)]-COBALT(III)) PERCHLORATE [J].
FENTON, RR ;
STEPHENS, FS ;
VAGG, RS ;
WILLIAMS, PA .
INORGANICA CHIMICA ACTA, 1992, 201 (02) :157-164
[44]   CHIRAL METAL-COMPLEXES .37. A NEW STEREOSPECIFIC N4 TETRADENTATE, N,N'-DI(2-PICOLYL)-N'-METHYL-2S-AMINOMETHYLPYRROLIDINE, S-PICPYRRME, AND THE CRYSTAL-STRUCTURES OF ITS TERNARY LAMBDA-ALPHA(1)-[CO(III)(S-PICPYRRME)(L)]2+ IONS (L = S-ALANINATE OR R-ALANINATE) [J].
FENTON, RR ;
STEPHENS, FS ;
VAGG, RS ;
WILLIAMS, PA .
INORGANICA CHIMICA ACTA, 1992, 197 (02) :233-242
[45]   CHIRAL METAL-COMPLEXES .31. ENHANCED ENANTIOSELECTIVITY IN A CO(III)-MEDIATED SYNTHESIS OF ALANINE, INCLUDING THE CRYSTAL-STRUCTURE OF THE INTERMEDIATE LAMBDA-BETA-1-[(3R,4R-DIPHENYL-1,6-DI(2-PYRIDYL)-2,5-DIAZAHEXANE)(2-AMINO-2-METHYLPROPANDIOICACIDATO)COBALT(III)] PERCHLORATE DIHYDRATE [J].
FENTON, RR ;
STEPHENS, FS ;
VAGG, RS ;
WILLIAMS, PA .
INORGANICA CHIMICA ACTA, 1991, 182 (01) :59-66
[46]   CHIRAL METAL-COMPLEXES .44. ENANTIOMERIC DISCRIMINATION IN TERNARY COBALT(III) COMPLEXES OF N,N'-DIMETHYL-N,N'-DI(2-PICOLYL)-1S,2S-DIAMINOCYCLOHEXANE AND ALPHA-AMINO-ACIDS - INCLUDING THE CRYSTAL-STRUCTURE OF THE S-PROLINATO COMPLEX [J].
FENTON, RR ;
STEPHENS, FS ;
VAGG, RS ;
WILLIAMS, PA .
INORGANICA CHIMICA ACTA, 1995, 236 (1-2) :109-115
[47]   TERNARY COMPLEXES IN SOLUTION .35. INTRAMOLECULAR HYDROPHOBIC LIGAND LIGAND INTERACTIONS IN MIXED-LIGAND COMPLEXES CONTAINING AN ALIPHATIC AMINO-ACID [J].
FISCHER, BE ;
SIGEL, H .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (09) :2998-3008
[48]   STERIC CONSTRAINTS IN FACULTATIVE LIGANDS - STEREOCHEMISTRY OF COBALT(III), NICKEL(II), COPPER(II), AND PALLADIUM(II) COMPOUNDS OF 2 HOMOLOGOUS TETRA-AMINES WITH TERMINAL PYRIDYL RESIDUES [J].
GIBSON, JG ;
MCKENZIE, ED .
JOURNAL OF THE CHEMICAL SOCIETY A -INORGANIC PHYSICAL THEORETICAL, 1971, (11) :1666-&
[49]   SYNTHESIS AND CHARACTERIZATION OF BIS(MU-OXO)DIMANGANESE(III,III), BIS(MU-OXO)DIMANGANESE(III,IV), AND BIS(MU-OXO)DIMANGANESE(IV,IV) COMPLEXES WITH LIGANDS RELATED TO N,N'-BIS(2-PYRIDYLMETHYL)-1,2-ETHANEDIAMINE (BISPICEN) [J].
GLERUP, J ;
GOODSON, PA ;
HAZELL, A ;
HAZELL, R ;
HODGSON, DJ ;
MCKENZIE, CJ ;
MICHELSEN, K ;
RYCHLEWSKA, U ;
TOFTLUND, H .
INORGANIC CHEMISTRY, 1994, 33 (18) :4105-4111
[50]   SYNTHESES AND CHARACTERIZATION OF BINUCLEAR MANGANESE(III,IV) AND MANGANESE(IV,IV) COMPLEXES WITH LIGANDS RELATED TO N,N'-BIS(2-PYRIDYLMETHYL)-1,2-ETHANEDIAMINE [J].
GOODSON, PA ;
GLERUP, J ;
HODGSON, DJ ;
MICHELSEN, K ;
WEIHE, H .
INORGANIC CHEMISTRY, 1991, 30 (26) :4909-4914
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