Live Birth Sex Ratio after In Vitro Fertilization and Embryo Transfer in China - An Analysis of 121,247 Babies from 18 Centers

被引：51

作者：

Bu, Zhiqin ^{[1
]}

Chen, Zi-Jiang ^{[3
]}

Huang, Guoning ^{[4
]}

Zhang, Hanwang ^{[5
]}

Wu, Qiongfang ^{[6
]}

Ma, Yanping ^{[7
]}

Shi, Juanzi ^{[8
]}

Xu, Yanwen ^{[9
]}

Zhang, Songying ^{[10
]}

Zhang, Cuilian ^{[11
]}

Zhao, Xiaoming ^{[12
]}

Zhang, Bo ^{[13
]}

Huang, Yuanhua ^{[14
]}

Sun, Zhengyi ^{[15
,16
]}

Kang, Yuefan ^{[17
]}

Wu, Riran ^{[18
]}

Wu, Xueqing ^{[19
]}

Sun, Haixiang ^{[2
]}

Sun, Yingpu ^{[1
]}

机构：

[1] Zhengzhou Univ, Reprod Med Ctr, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China

[2] Nanjing Univ, Nanjing Drum Tower Hosp, Reprod Med Ctr, Nanjing 210008, Jiangsu, Peoples R China

[3] Shandong Univ, Ctr Reprod Med, Prov Hosp, Jinan 250100, Peoples R China

[4] Chongqing Obstet & Gynecol Hosp, Chongqing Reprod & Genet Inst, Chongqing, Peoples R China

[5] Huazhong Univ Sci & Technol, Reprod Med Ctr, Tongji Hosp, Wuhan 430074, Peoples R China

[6] Women & Children Hosp Jiangxi Prov, Reprod Med Ctr, Nanchang, Peoples R China

[7] First Peoples Hosp Yunnan Prov, Reprod Med Ctr, Kunming, Peoples R China

[8] Maternal & Child Hlth Care Hosp Shaanxi Prov, Reprod Med Ctr, Xian, Peoples R China

[9] Sun Yat Sen Univ, Reprod Med Ctr, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China

[10] Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Reprod Med Ctr, Hangzhou 310003, Zhejiang, Peoples R China

[11] Henan Prov Peoples Hosp, Reprod Med Ctr, Zhengzhou, Peoples R China

[12] Shanghai Jiao Tong Univ, Reprod Med Ctr, Renji Hosp, Shanghai 200030, Peoples R China

[13] Maternal & Child Hlth Hosp Guangxi Zhuang Autonom, Reprod Med Ctr, Nanning, Peoples R China

[14] Hainan Med Coll, Reprod Med Ctr, Affiliated Hosp, Haikou, Peoples R China

[15] Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Obstet & Gynecol, Beijing 100021, Peoples R China

[16] Chinese Acad Med Sci, Beijing 100730, Peoples R China

[17] Maternal & Childrens Hlth Hosp Fujian Prov, Reprod Med Ctr, Fuzhou, Peoples R China

[18] Boai Hosp Zhongshan, Reprod Med Ctr, Zhongshan, Peoples R China

[19] Women & Childrens Hosp Shanxi Prov, Reprod Med Ctr, Taiyuan, Peoples R China

来源：

PLOS ONE | 2014年 / 9卷 / 11期

关键词：

ASSISTED REPRODUCTIVE TECHNOLOGY; BLASTOCYST TRANSFER; INFANTS BORN; IMPACT; STAGE;

D O I：

10.1371/journal.pone.0113522

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In order to study the impact of procedures of IVF/ICSI technology on sex ratio in China, we conducted this multi-center retrospective study including 121,247 babies born to 93,895 women in China. There were 62,700 male babies and 58,477 female babies, making the sex ratio being 51.8% (Male: Female = 107: 100). In univariate logistic regression analysis, sex ratio was imbalance toward females of 50.3% when ICSI was preformed compared to 47.7% when IVF was used (P < 0.01). The sex ratio in IVF/ICSI babies was significantly higher toward males in transfers of blastocyst (54.9%) and thawed embryo (52.4%) when compared with transfers of cleavage stage embryo (51.4%) and fresh embryo (51.5%), respectively. Multiple delivery was not associated with sex ratio. However, in multivariable logistic regression analysis after controlling for related factors, only ICSI (adjusted OR = 0.90, 95%CI: 0.88-0.93; P < 0.01) and blastocyst transfer (adjusted OR = 1.14, 95% CI: 1.09-1.20; P < 0.01) were associated with sex ratio in IVF/ICSI babies. In conclusion, the live birth sex ratio in IVF/ICSI babies was influenced by the use of ICSI, which may decrease the percentage of male offspring, or the use of blastocyst transfer, which may increase the percentage of male offspring.

引用

页数：6

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