Neosappanone A, a xanthine oxidase (XO) inhibitory dimeric methanodibenzoxocinone with a new carbon skeleton from Caesalpinia sappan

被引：18

作者：

Nguyen, MTT ^{[1
]}

Awale, S ^{[1
]}

Tezuka, Y ^{[1
]}

Le Tran, Q ^{[1
]}

Kadota, S ^{[1
]}

机构：

[1] Toyama Med & Pharmaceut Univ, Inst Nat Med, Sugitani, Toyama 9300194, Japan

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 46期

关键词：

new carbon skeleton; dimeric methanodibenzoxocinone; xanthine oxidase (XO) inhibitory activity; Caesalpinia sappan;

D O I：

10.1016/j.tetlet.2004.09.107

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel dimeric methanodibenzoxocinone, named neosappanone A (1), possessing a unique unprecedented novel carbon framework, has been isolated from the heartwood of Caesalpinia sappan L. of Vietnam, and its structure was elucidated on the basis of spectroscopic analysis. Neosappanone A (1) competitively inhibited xanthine oxidase in a concentration-dependent manner (IC50, 29.7 muM; K-i, 16.3 muM). (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：8519 / 8522

页数：4