Metabolic Syndrome and Amyloid Accumulation in the Aging Brain

被引：47

作者：

Gomez, Gabriela ^{[1
]}

Beason-Held, Lori L. ^{[1
]}

Bilgel, Murat ^{[1
]}

An, Yang ^{[1
]}

Wong, Dean E. ^{[2
]}

Studenski, Stephanie ^{[1
]}

Ferrucci, Luigi ^{[1
]}

Resnick, Susan M. ^{[1
]}

机构：

[1] NIA, Intramural Res Program, NIH, Baltimore, MD 21224 USA

[2] Johns Hopkins Med Inst, Dept Radiol, Baltimore, MD 21205 USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2018年 / 65卷 / 02期

关键词：

Alzheimer's disease; amyloid PET; brain; cholesterol; dementia; diabetes; hypertension; metabolic syndrome; vascular; CEREBRAL-BLOOD-FLOW; ALZHEIMERS-DISEASE; INSULIN-RESISTANCE; COGNITIVE IMPAIRMENT; RISK-FACTOR; BETA; DEMENTIA; OLDER; DEPOSITION; PATHOLOGY;

D O I：

10.3233/JAD-180297

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Recent studies showlinks between metabolic syndrome and Alzheimer's disease (AD) neuropathology. Understanding the link between vascular-related health conditions and dementia will help target at risk populations and inform clinical strategies for early detection and prevention of AD. Objective: To determine whether metabolic syndrome is associated with global cerebral amyloid-beta (A beta) positivity and longitudinal A beta accumulation. Methods: Prospective study of 165 participants who underwent (11) C-Pittsburgh compound B (PiB) PET neuroimaging to measure A beta, from June 2005 to May 2016. Metabolic syndrome was defined using the revised Third Adults Treatment Panel of the National Cholesterol Education Program criteria. Participants were classified as PiB+/-. Linear mixed effects models assessed the relationships between baseline metabolic syndrome and PiB status and regional A beta change over time. Results: A total of 165 cognitively normal participants of the Baltimore Longitudinal Study of Aging (BLSA) Neuroimaging substudy, aged 55-92 years (mean baseline age = 76.4 years, 85 participants were male), received an average of 2.5 PET-PiB scans over an average interval of 2.6 (3.08 SD) years between first and last visits. Metabolic syndrome was not associated with baseline PiB positivity or concurrent regional A beta. Metabolic syndrome was associated with increased rates of A beta accumulation in superior parietal and precuneus regions over time in the PiB+ group. Elevated fasting glucose and blood pressure showed individual associations with accelerated A beta accumulation. Conclusion: Metabolic syndrome was associated with accelerated A beta accumulation in PiB+ individuals and may be an important factor in the progression of AD pathology.

引用

页码：629 / 639

页数：11

共 67 条

[1] The vascular contribution to Alzheimer's disease [J].

Altman, Robin ;

Rutledge, John C. .

CLINICAL SCIENCE, 2010, 119 (9-10) :407-421

[2]

Alzheimer's Association, 2016, Alzheimers Dement, V12, P459

[3] Evidence for brain glucose dysregulation in Alzheimer's disease [J].

An, Yang ;

Varma, Vijay R. ;

Varma, Sudhir ;

Casanova, Ramon ;

Dammer, Eric ;

Pletnikova, Olga ;

Chia, Chee W. ;

Egan, Josephine M. ;

Ferrucci, Luigi ;

Troncoso, Juan ;

Levey, Allan I. ;

Lah, James ;

Seyfried, Nicholas T. ;

Legido-Quigley, Cristina ;

O'Brien, Richard ;

Thambisetty, Madhav .

ALZHEIMERS & DEMENTIA, 2018, 14 (03) :318-329

[4] Symmetric diffeomorphic image registration with cross-correlation: Evaluating automated labeling of elderly and neurodegenerative brain [J].

Avants, B. B. ;

Epstein, C. L. ;

Grossman, M. ;

Gee, J. C. .

MEDICAL IMAGE ANALYSIS, 2008, 12 (01) :26-41

[5] Longitudinal changes in cerebral blood flow in the older hypertensive brain [J].

Beason-Held, Lori L. ;

Moghekar, Abhay ;

Zonderman, Alan B. ;

Kraut, Michael A. ;

Resnick, Susan M. .

STROKE, 2007, 38 (06) :1766-1773

[6] Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease [J].

Bell, Robert D. ;

Zlokovic, Berislav V. .

ACTA NEUROPATHOLOGICA, 2009, 118 (01) :103-113

[7]

Benaglia T, 2009, J STAT SOFTW, V32, P1

[8] CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING [J].

BENJAMINI, Y ;

HOCHBERG, Y .

JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) :289-300

[9] DIFFERENTIAL BEHAVIORAL EFFECTS IN FRONTAL LOBE DISEASE [J].

BENTON, AL .

NEUROPSYCHOLOGIA, 1968, 6 (01) :53-&

[10] Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease [J].

Benzinger, Tammie L. S. ;

Blazey, Tyler ;

Jack, Clifford R., Jr. ;

Koeppe, Robert A. ;

Su, Yi ;

Xiong, Chengjie ;

Raichle, Marcus E. ;

Snyder, Abraham Z. ;

Ances, Beau M. ;

Bateman, Randall J. ;

Cairns, Nigel J. ;

Fagan, Anne M. ;

Goate, Alison ;

Marcus, Daniel S. ;

Aisen, Paul S. ;

Christensen, Jon J. ;

Ercole, Lindsay ;

Hornbeck, Russ C. ;

Farrar, Angela M. ;

Aldea, Patricia ;

Jasielec, Mateusz S. ;

Owen, Christopher J. ;

Xie, Xianyun ;

Mayeux, Richard ;

Brickman, Adam ;

McDade, Eric ;

Klunk, William ;

Mathis, Chester A. ;

Ringman, John ;

Thompson, Paul M. ;

Ghetti, Bernardino ;

Saykin, Andrew J. ;

Sperling, Reisa A. ;

Johnson, Keith A. ;

Salloway, Stephen ;

Correia, Stephen ;

Schofield, Peter R. ;

Masters, Colin L. ;

Rowe, Christopher ;

Villemagne, Victor L. ;

Martins, Ralph ;

Ourselin, Sebastien ;

Rossor, Martin N. ;

Fox, Nick C. ;

Cash, David M. ;

Weiner, Michael W. ;

Holtzman, David M. ;

Buckles, Virginia D. ;

Moulder, Krista ;

Morris, John C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (47) :E4502-E4509

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