Multicomponent decarboxylative allylations

被引：9

作者：

Ariyarathna, Yamuna ^{[1
]}

Tunge, Jon A. ^{[1
]}

机构：

[1] Univ Kansas, Dept Chem, Lawrence, KS 66045 USA

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 90期

基金：

美国国家科学基金会;

关键词：

ASYMMETRIC ALLYLIC ALKYLATION; CROSS-COUPLING REACTIONS; CLAISEN REARRANGEMENT REACTIONS; ESTER ENOLATE EQUIVALENTS; ELECTROPHILICITY PARAMETERS; CATALYZED DECARBOXYLATION; TOSYLMALONATE ESTERS; ACTIVATED OLEFINS; ACID DERIVATIVES; BETA-KETOESTERS;

D O I：

10.1039/c4cc07253g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reaction of Meldrum's acid, pyrrolide, and allyl carbonates allows a multicomponent decarboxylative coupling to form allylated acyl pyrroles. This strategy is made possible by the in situ formation of beta-oxo carboxylates from Meldrum's acid. Subsequent decarboxylative enolate formation and electrophilic allylation complete the reaction. Addition of benzylidene malononitriles as good Michael acceptors allow a 4-component interceptive decarboxylative allylation

引用

页码：14049 / 14052

页数：4

共 58 条

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