Synthesis and characterization of new 3-(4,5-dihydro-5-aryl)isoxazol-3-yl)-4-hydroxyquinolin-2(1H)-ones and 3-(4-styryl)isoxazolo[4,5-c]quinolin-4(5H)-one derivatives

被引:8
作者
Sarveswari, S. [1 ]
Vijayakumar, V. [1 ]
机构
[1] VIT Univ, Sch Adv Sci, Organ Chem Div, Vellore 632014, Tamil Nadu, India
关键词
Synthesis of 4-hydroxy-3-(3-arylacryloyl)quinolin-2(1H)-ones; 3-(4,5-Dihydro-5-aryl)isoxazol-3-yl)-4-hydroxyquinolin-2(1H)-ones; 3-(4-Styryl)isoxazolo[4,5-c]quinolin-4(5H)-ones; ISOXAZOLES; ANTAGONISTS; QUINOLONES;
D O I
10.1016/j.arabjc.2011.09.020
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The 4-hydroxy-3-(3-arylacryloyl)quinolin-2(1H)-ones were synthesized from 3-acetyl-4-hydroxyquinolin-2(1H)-one by microwave assisted synthesis, which in turn converted into their corresponding 3-(4,5-dihydro-5-aryl)isoxazol-3-yl)-4-hydroxyquinolin-2(1H)-ones and 3-(4-styryl)isoxazolo[4,5-c]quinolin-4(5H)-one derivatives. (C) 2011 Production and hosting by Elsevier B.V. on behalf of King Saud University.
引用
收藏
页码:S835 / S839
页数:5
相关论文
共 25 条
[1]   Peptidomimetics - Antagonists of the fibrinogen receptors: Molecular design, structures, properties and therapeutic applications [J].
Andronati, SA ;
Karaseva, TL ;
Krysko, AA .
CURRENT MEDICINAL CHEMISTRY, 2004, 11 (09) :1183-1211
[2]   Quinolone activity against anaerobes [J].
Appelbaum, PC .
DRUGS, 1999, 58 (Suppl 2) :60-64
[3]  
Balalaie S, 2000, INDIAN J HETEROCY CH, V10, P149
[4]   Novel δ2-isoxazolines as group II phospholipase A2 inhibitors [J].
Basappa ;
Kumar, MS ;
Swamy, SN ;
Mahendra, M ;
Prasad, JS ;
Viswanath, BS ;
Rangappa, KS .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (14) :3679-3681
[5]   Synthesis of cis and trans isomers of an isoxazoline ring-hydroxylated metabolite of Roxifiban, a platelet glycoprotein IIb/IIIa receptor antagonist [J].
Batt, DG ;
Houghton, GC ;
Daneker, WF ;
Jadhav, PK .
JOURNAL OF ORGANIC CHEMISTRY, 2000, 65 (23) :8100-8104
[6]   A convenient, rapid and eco-friendly synthesis of isoxazoline heterocyclic moiety containing bridge at 2°-amine as potential pharmacological agent [J].
Desai, J. T. ;
Desai, C. K. ;
Desai, K. R. .
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2008, 5 (01) :67-73
[7]   3,4,5-trisubstituted isoxazoles as novel PPARδ agonists:: Part 1 [J].
Epple, Robert ;
Russo, Ross ;
Azimioara, Mihai ;
Cow, Christopher ;
Xie, Yongping ;
Wang, Xing ;
Wityak, John ;
Karanewsky, Don ;
Gerken, Andrea ;
Iskandar, Maya ;
Saez, Enrique ;
Seidel, H. Martin ;
Tian, Shin-Shay .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (16) :4376-4380
[8]   REACTION OF VINYL KETOXIMES WITH N-BROMOSUCCINIMIDE - SYNTHESIS OF ISOXAZOLES AND 4-BROMOISOXAZOLINES [J].
HANSEN, JF ;
STRONG, SA .
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1977, 14 (07) :1289-1289
[9]  
Hooper D., 2000, MANDELL DOUGLAS BENN, V5th, P404
[10]   New uses for new and old quinolones and the challenge of resistance [J].
Hooper, DC .
CLINICAL INFECTIOUS DISEASES, 2000, 30 (02) :243-254