Comparative Pharmacokinetics of Ceftaroline in Rats, Rabbits, and Monkeys following a Single Intravenous or Intramuscular Injection

被引：13

作者：

Ge, Yigong ^{[1
]}

Maynard, David ^{[2
]}

Rickert, Douglas E. ^{[3
]}

机构：

[1] Cerexa Inc, Oakland, CA USA

[2] LAB Res Inc, Laval, PQ, Canada

[3] Douglas E Rickert LLC, Raleigh, NC USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 02期

关键词：

THERAPEUTIC EFFICACY; INFECTION MODELS; DOSING INTERVALS; CEPHALOSPORIN; PHARMACODYNAMICS; COLLECTION; PNEUMONIA; STRAINS; THIGH;

D O I：

10.1128/AAC.00645-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This study assessed the pharmacokinetic profiles for intramuscular and intravenous ceftaroline treatment for rats, rabbits, and monkeys. Ceftaroline, a novel cephalosporin with broad-spectrum activity against Gram-positive and Gram-negative pathogens, demonstrated favorable pharmacokinetic profiles following intramuscular administration in all 3 animal species, comparable to the levels for intravenous dosing. The areas under the plasma concentration-time curve obtained after intramuscular administration were increased in rats and similar in rabbits and monkeys, compared with the levels obtained after intravenous dosing (129%, 7.29%, and 12.7% greater in rats, rabbits, and monkeys, respectively). The data reported here support the development of an intramuscular formulation for ceftaroline.

引用

页码：912 / 914

页数：3

共 14 条

[1] Pharmacodynamics of a new cephalosporin, PPI-0903 (TAK-599), active against methicillin-resistant Staphylococcus aureus in murine thigh and lung infection models:: Identification of an in vivo pharmacokinetic-pharmacodynamic target [J].