Autophagy in Cardiovascular Aging

被引：204

作者：

Abdellatif, Mahmoud ^{[1
]}

Sedej, Simon ^{[1
,2
]}

Carmona-Gutierrez, Didac ^{[2
,3
]}

Madeo, Frank ^{[2
,3
]}

Kroemer, Guido ^{[4
,5
,6
,7
,8
,9
,10
]}

机构：

[1] Med Univ Graz, Dept Cardiol, Graz, Austria

[2] BioTechMed Graz, Graz, Austria

[3] Karl Franzens Univ Graz, NAWI Graz, Inst Mol Biosci, Graz, Austria

[4] Ctr Rech Cordeliers, Equipe Labellisee Ligue Canc 11, Paris, France

[5] Gustave Roussy Comprehens Canc Ctr, Cell Biol & Metabol Platforms, Villejuif, France

[6] INSERM, U1138, Paris, France

[7] Univ Paris 05, Sorbonne Paris Cite, Paris, France

[8] Univ Paris 06, Paris, France

[9] Hop Europeen Georges Pompidou, Pole Biol, Paris, France

[10] Karolinska Univ Hosp, Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden

来源：

CIRCULATION RESEARCH | 2018年 / 123卷 / 07期

基金：

欧洲研究理事会; 奥地利科学基金会;

关键词：

autophagy; caloric restriction; cardiovascular diseases; heart; longevity; VASCULAR ENDOTHELIAL DYSFUNCTION; LIFE-SPAN EXTENSION; NITRIC-OXIDE BIOAVAILABILITY; ACTIVATED PROTEIN-KINASE; TERM CALORIC RESTRICTION; CARDIAC-SPECIFIC OVEREXPRESSION; MUSCLE-CELL SENESCENCE; CORONARY-HEART-DISEASE; FACTOR-I RECEPTOR; OXIDATIVE STRESS;

D O I：

10.1161/CIRCRESAHA.118.312208

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiovascular diseases are the most prominent maladies in aging societies. Indeed, aging promotes the structural and functional declines of both the heart and the blood circulation system. In this review, we revise the contribution of known longevity pathways to cardiovascular health and delineate the possibilities to interfere with them. In particular, we evaluate autophagy, the intracellular catabolic recycling system associated with life - and health-span extension. We present genetic models, pharmacological interventions, and dietary strategies that block, reduce, or enhance autophagy upon age-related cardiovascular deterioration. Caloric restriction or caloric restriction mimetics like metformin, spermidine, and rapamycin (all of which trigger autophagy) are among the most promising cardioprotective interventions during aging. We conclude that autophagy is a fundamental process to ensure cardiac and vascular health during aging and outline its putative therapeutic importance.

引用

页码：803 / 824

页数：22

共 251 条

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