ESI-MS characterisation of protein adducts of anticancer ruthenium(II)-arene PTA (RAPTA) complexes

被引：86
|
作者：
Casini, Angela
Mastrobuoni, Guido
Ang, Wee Han
Gabbiani, Chiara
Pieraccini, Giuseppe
Moneti, Gloriano
Dyson, Paul J.
Messori, Luigi
机构：
[1] Department of Chemistry, University of Florence, 50019 Sesto Fiorentino
[2] Mass Spectrometry Centre, University of Florence, 50019 Sesto Fiorentino
[3] Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL)
来源：
CHEMMEDCHEM | 2007年 / 2卷 / 05期
关键词：
D O I：
10.1002/cmdc.200600258
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Electrospray ionization mass spectrometry allows a rapid characterisation of the adducts formed between three novel anticancer ruthenium(II)-arene PTA compounds and horse heart cytochromec or hen egg white lysozyme. Specific information on the nature of the protein-bound metallic fragments and the extent of protein metallation was readily obtained.
引用
收藏
页码：631 / +
页数：6
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