Synthesis of purine conjugates with N-(4-aminobenzenesulfonyl)-and N-(2-aminoethanesulfonyl)-(S)-glutamic acids

被引：0

作者：

Vigorov, A. Yu. ^{[1
]}

Gorbunov, E. B. ^{[1
]}

Ezhikova, M. A. ^{[1
]}

Kodess, M. I. ^{[1
]}

Belyaev, D. V. ^{[1
,2
]}

Vakhrusheva, D. V. ^{[2
]}

Levit, G. L. ^{[1
]}

Krasnov, V. P. ^{[1
]}

机构：

[1] Ural Branch Russian Acad Sci, I Ya Postovsky Inst Organ Synth, 22-20 ul S Kovalevskoi, Ekaterinburg 620108, Russia

[2] Russian Federat, Ural Res Inst Phthisiopulmonol, Natl Med Res Ctr Phthisiopulmonol & Infect Dis, Minist Hlth, 50 ul 22-20 Partsezda, Ekaterinburg 620039, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2022年 / 71卷 / 12期

基金：

俄罗斯科学基金会;

关键词：

purines; adenine; sulfanilic acid; taurine; glutamic acid; antimycobacterial activity; ANTIMYCOBACTERIAL ACTIVITY; ADENOSINE RECEPTORS; N-(2-AMINOPURIN-6-YL); DERIVATIVES;

D O I：

10.1007/s11172-022-3697-6

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The approaches to the synthesis of purine conjugates with N-(4-aminobenzenesulfonyl)-(S)-glutamic acid and N-(2-ammoethanesulfonyl)-(S)-glutamic acid by nucleophilic substitution of chlorine atom in 6-chloropurine derivatives have been developed. The studied compounds did not show significant antimycobacterial activity in the in vitro experiment.

引用

页码：2685 / 2690

页数：6

共 26 条

[1]

[Anonymous], 2016, Pat., Patent No. [RU2604068, 2604068]

[2] PHARMACOLOGY OF ADENOSINE RECEPTORS: THE STATE OF THE ART [J].

Borea, Pier Andrea ;

Gessi, Stefania ;

Merighi, Stefania ;

Vincenzi, Fabrizio ;

Varani, Katia .

PHYSIOLOGICAL REVIEWS, 2018, 98 (03) :1591-1625

[3]

F Armarego W.L., 2013, Purification of Laboratory Chemicals, VSeventh

[4] Purine derivatives with antituberculosis activity [J].

Gruzdev, Dmitry A. ;

Musiyak, Vera V. ;

Levit, Galina L. ;

Krasnov, Victor P. ;

Charushin, Valery N. .

RUSSIAN CHEMICAL REVIEWS, 2018, 87 (06) :604-618

[5] Synthesis and antimycobacterial activity of novel purin-6-yl and 2-aminopurin-6-yl conjugates with (S)-aspartic and (S)-glutamic acids [J].

Gruzdev, Dmitry A. ;

Chulakov, Evgeny N. ;

Levit, Galina L. ;

Kravchenko, Marionella A. ;

Krasnov, Victor P. ;

Charushin, Valery N. .

MENDELEEV COMMUNICATIONS, 2017, 27 (06) :547-549

[6] Adenosine receptors as therapeutic targets [J].

Jacobson, KA ;

Gao, ZG .

NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (03) :247-264

[7]

Jones J I., 1980, BRIT POLYM J, V12, P192, DOI [10.1002/pi.4980120412, DOI 10.1002/PI.4980120412]

[8] Synthesis of Purine and 2-Aminopurine Conjugates with N-(4-Aminobenzoyl)-(S)-glutamic Acid [J].

Krasnov, V. P. ;

Vigorov, A. Yu. ;

Chulakov, E. N. ;

Nizova, I. A. ;

Levit, G. L. ;

Kravchenko, M. A. ;

Charushin, V. N. .

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2019, 55 (06) :755-761

[9] Synthesis of enantiomers of N-(2-aminopurin-6-yl) amino acids [J].

Krasnov, V. P. ;

Vigorov, A. Yu. ;

Gruzdev, D. A. ;

Levit, G. L. ;

Demin, A. M. ;

Nizova, I. A. ;

Tumashov, A. A. ;

Sadretdinova, L. Sh. ;

Gorbunov, E. B. ;

Charushin, V. N. .

RUSSIAN CHEMICAL BULLETIN, 2015, 64 (09) :2106-2113

[10] Fragment-based approach to novel bioactive purine derivatives [J].

Krasnov, Victor P. ;

Levit, Galina L. ;

Musiyak, Vera V. ;

Gruzdev, Dmitry A. ;

Charushin, Valery N. .

PURE AND APPLIED CHEMISTRY, 2020, 92 (08) :1277-1295

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