Cancer stem cell research in Iran: potentials and challenges

被引:0
作者
Roudi, Raheleh [1 ]
Ebrahimi, Marzieh [2 ]
Shariftabrizi, Ahmad [3 ]
Madjd, Zahra [1 ,4 ]
机构
[1] Iran Univ Med Sci, Oncopathol Res Ctr, Tehran, Iran
[2] ACECR, Dept Stem Cells & Dev Biol, Cell Sci Res Ctr, Royan Inst Stem Cell Biol & Technol, Tehran, Iran
[3] SUNY Buffalo, Dept Nucl Med & Mol Imaging, Buffalo, NY 14214 USA
[4] Iran Univ Med Sci, Fac Adv Technol Med, Dept Mol Med, Tehran, Iran
关键词
cancer stem cells; Iran; tumor-initiating cells; ACUTE MYELOID-LEUKEMIA; DIFFERENTIAL EXPRESSION; PROSTATE-CANCER; CYCLE ARREST; PROSPECTIVE IDENTIFICATION; MESENCHYMAL TRANSITION; DOCETAXEL CONJUGATE; DOWN-REGULATION; UP-REGULATION; MARKERS CD44;
D O I
10.2217/fon-2017-0091
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Treatment modalities can reduce cancer-related mortality; however, a majority of patients develop drug resistance, metastasis and relapse. It has been proposed that tumorigenic characteristics of tumors are related to a proportion of cancer cells, termed cancer stem cells (CSCs). Following the first evidence regarding the existence of CSC population in acute myeloid leukemia in 1997, publications in CSCs field showed an explosive trend in all cancer types around the world. First research paper in the field of CSCs in Iran was published in 2004 on prostate cancer. Subsequently, an annual number of publications in the field of CSCs displayed a rapidly growing trend. Therefore, in the current review, we have presented a comprehensive evaluation of the CSCs research in Iran.
引用
收藏
页码:1809 / 1826
页数:18
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