Structure-activity relationships (SAR) of triazine derivatives: Promising antimicrobial agents

被引：88
作者：
Liu, Hao [1 ]
Long, Sihui [1 ]
Rakesh, K. P. [1 ]
Zha, Gao-Feng [1 ,2 ]
机构：
[1] Wuhan Inst Technol, Hubei Key Lab Novel Reactor & Green Chem Technol, Hubei Engn Res Ctr Adv Fine Chem, Key Lab Green Chem Proc,Minist Educ,Sch Chem Engn, Wuhan 430205, Hubei, Peoples R China
[2] Karolinska Inst, Ming Wai Lau Ctr Reparat Med, Hong Kong, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2020年 / 185卷
基金：
中国国家自然科学基金;
关键词：
Triazines; Antibacterial; Antifungal; Minimum inhibitory concentration; SAR; ANTIBACTERIAL ACTIVITY; STAPHYLOCOCCUS-AUREUS; BIOLOGICAL EVALUATION; ANTITUMOR-ACTIVITY; MOLECULAR DOCKING; DESIGN; POTENT; INHIBITORS; DISCOVERY; ANALOGS;
D O I：
10.1016/j.ejmech.2019.111804
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The emergence of drug resistance has created unmet medical need for the development of new classes of antibiotics. Innovation of new antibacterial agents with new mode of action remains a high priority universally. Triazines are six-membered, nitrogen-containing heterocyclic scaffold with a wide range of pharmaceutical properties such as antibacterial, antifungal, anticancer, antioxidants, antitubercular, antimalarial, anti-HIV, anticonvulsant, anti-inflammatory, antiulcer, and analgesic activities. The present review focuses on the recent developments in the area of medicinal chemistry to discover various chemical structures as potential antimicrobial agents and their structure-activity relationships (SAR) studies are also discussed for further rational design of this kind of derivatives. (C) 2019 Elsevier Masson SAS. All rights reserved.
引用
收藏
页数：15
相关论文
共 50 条
  • [21] Synthesis, Antimicrobial Activity, Structure-Activity Relationship, and Molecular Docking Studies of Indole Diketopiperazine Alkaloids
    Jia, Bin
    Ma, Yang-min
    Liu, Bin
    Chen, Pu
    Hu, Yan
    Zhang, Rui
    [J]. FRONTIERS IN CHEMISTRY, 2019, 7
  • [22] Structure-Activity Relationships of Pyrimidine Derivatives and their Biological Activity-A Review
    Natarajan, Ramalakshmi
    Samy, Helina Navis Anthoni
    Sivaperuman, Amuthalakshmi
    Subramani, Arunkumar
    [J]. MEDICINAL CHEMISTRY, 2023, 19 (01) : 10 - 30
  • [23] Design, synthesis, and structure-activity relationships of pyrazole derivatives as potential FabH inhibitors
    Lv, Peng-Cheng
    Sun, Juan
    Luo, Yin
    Yang, Ying
    Zhu, Hai-Liang
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (15) : 4657 - 4660
  • [24] Synthesis and structure-activity relationship of amidine derivatives of 3,4-ethylenedioxythiophene as novel antibacterial agents
    Stolic, Ivana
    Paljetak, Hana Cipcic
    Peric, Mihaela
    Matijasic, Mario
    Stepanic, Visnja
    Verbanac, Donatella
    Bajic, Miroslav
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 90 : 68 - 81
  • [25] Design, synthesis and structure-activity relationships of novel 4-phenoxyquinoline derivatives containing pyridazinone moiety as potential antitumor agents
    Zhou, Shunguang
    Liao, Huimin
    He, Chao
    Dou, Yanan
    Jiang, Mingyan
    Ren, Lixiang
    Zhao, Yanfang
    Gong, Ping
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 83 : 581 - 593
  • [26] Synthesis, Structure-Activity Relationships (SAR) and in Silico Studies of Coumarin Derivatives with Antifungal Activity
    de Araujo, Rodrigo S. A.
    Guerra, Felipe Q. S.
    Lima, Edeltrudes de O.
    de Simone, Carlos A.
    Tavares, Josean F.
    Scotti, Luciana
    Scotti, Marcus T.
    de Aquino, Thiago M.
    de Moura, Ricardo O.
    Mendonca, Francisco J. B., Jr.
    Barbosa-Filho, Jose M.
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2013, 14 (01) : 1293 - 1309
  • [27] Structure-activity relationships of tetrahydrocarbazole derivatives as antifungal lead compounds
    Wang, Wenya
    Dong, Guoqiang
    Gu, Julin
    Zhang, Yongqiang
    Wang, Shengzheng
    Zhu, Shiping
    Liu, Yang
    Miao, Zhenyuan
    Yao, Jianzhong
    Zhang, Wannian
    Sheng, Chunquan
    [J]. MEDCHEMCOMM, 2013, 4 (02) : 353 - 362
  • [28] Antimicrobial activity and structure-activity relationships of molecules containing mono- or di- or oligosaccharides: An update
    Zhou, Tiantian
    Hao, Jiongkai
    Tang, Qun
    Chandarajoti, Kasemsiri
    Ye, Wenchong
    Fan, Chuangchuang
    Wang, Xiaoyang
    Wang, Chunmei
    Zhang, Keyu
    Han, Xiangan
    Zhou, Wen
    Ge, Yuewei
    [J]. BIOORGANIC CHEMISTRY, 2024, 148
  • [29] Synthesis and structure-activity relationships of asymmetric dimeric β-carboline derivatives as potential antitumor agents
    Guo, Liang
    Chen, Wei
    Cao, Rihui
    Fan, Wenxi
    Ma, Qin
    Zhang, Jie
    Dai, Bin
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 147 : 253 - 265
  • [30] Structure-Activity Relationships for Poly(phenylene)vinylene Derivatives as Antibacterial Agents
    Tolosa, Juan
    Serrano de las Heras, Gemma
    Carrion, Blanca
    Segura, Tomas
    Paez, Paulina L.
    de Lera-Garrido, Fernando J.
    Rodriguez-Lopez, Julian
    Garcia-Martinez, Joaquin C.
    [J]. CHEMISTRYSELECT, 2018, 3 (25): : 7327 - 7332
12345