Photodynamic Therapy Based on Graphene and MXene in Cancer Theranostics

被引：125

作者：

Gazzi, Arianna ^{[1
,2
]}

Fusco, Laura ^{[1
,2
,3
]}

Khan, Anooshay ^{[4
]}

Bedognetti, Davide ^{[3
]}

Zavan, Barbara ^{[5
,6
]}

Vitale, Flavia ^{[7
,8
]}

Yilmazer, Acelya ^{[4
,9
]}

Delogu, Lucia Gemma ^{[2
,10
]}

机构：

[1] Univ Trieste, Dept Chem & Pharmaceut Sci, Trieste, Italy

[2] Fdn Ist Ric Pediat Citta Speranza, Padua, Italy

[3] Sidra Med & Res Ctr, Doha, Qatar

[4] Univ Ankara, Dept Biomed Engn, Ankara, Turkey

[5] Univ Ferrara, Dept Med Sci, Ferrara, Italy

[6] GVM Care & Res, Maria Cecilia Hosp, Ravenna, Italy

[7] Univ Penn, Ctr Neuroengn & Therapeut, Dept Neurol Bioengn Phys Med & Rehabil, Philadelphia, PA 19104 USA

[8] Corporal Michael J Crescenz Vet Affairs Med Ctr, Ctr Neurotrauma Neurodegenerat & Restorat, Philadelphia, PA 19104 USA

[9] Univ Ankara, Stem Cell Inst, Ankara, Turkey

[10] Univ Padua, Dept Biomed Sci, Padua, Italy

来源：

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2019年 / 7卷 / OCT期

关键词：

photodynamic therapy; theranostics; graphene; MXene; nanomedicine; NANO-GRAPHENE; QUANTUM DOTS; CHEMICAL FUNCTIONALIZATION; CARBIDE MXENE; TI3C2; MXENE; OXIDE; DELIVERY; NANOSHEETS; PHOTOSENSITIZERS; FLUORESCENCE;

D O I：

10.3389/fbioe.2019.00295

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cancer is one of the leading causes of death in the world. Therefore, the development of new advanced and targeted strategies in cancer research for early diagnosis and treatment has become essential to improve diagnosis outcomes and reduce therapy side effects. Graphene and more recently, MXene, are the main representatives of the family of two-dimensional (2D) materials and are widely studied as multimodal nanoplatforms for cancer diagnostics and treatment, in particular leveraging their potentialities as photodynamic therapeutic agents. Indeed, due to their irreplaceable physicochemical properties, they are virtuous allies for photodynamic therapy (PDT) in combination with bioimaging, photothermal therapy, as well as drug and gene delivery. In this review, the rapidly progressing literature related to the use of these promising 2D materials for cancer theranostics is described in detail, highlighting all their possible future advances in PDT.

引用

页数：15

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