Catalytic Gold Chemistry: From Simple Salts to Complexes for Regioselective C-H Bond Functionalization

被引：25

作者：

Praveen, Chandrasekar ^{[1
]}

Dupeux, Aurelien ^{[2
]}

Michelet, Veronique ^{[2
]}

机构：

[1] Cent Electrochem Res Inst, CSIR Lab, Electrochem Power Sources Div, Karaikkudi 630003, Tamil Nadu, India

[2] Univ Cote dAzur, Inst Chim Nice, UMR CNRS 7272, Fac Sci, Valrose Pk, F-06108 Nice 2, France

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2021年 / 27卷 / 41期

关键词：

C-H activation; contributing factors; gold catalysis; regioselectivity; site selectivity; UGI INTRAMOLECULAR HYDROARYLATION; TETRACYCLIC INDOLE-DERIVATIVES; CONCISE TOTAL-SYNTHESIS; DIRECT ALKYNYLATION; TERMINAL ALKYNES; HIGHLY EFFICIENT; 3-COMPONENT REACTION; SELECTIVE SYNTHESIS; STRUCTURAL-CHARACTERIZATION; ORGANOMETALLIC CHEMISTRY;

D O I：

10.1002/chem.202100785

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gold coordinated to neutral phosphines (R3P), N-heterocyclic carbenes (NHCs) or anionic ligands is catalytically active in functionalizing various C-H bonds with high selectivity. The sterics/electronic nature of the studied C-H bond, oxidation state of gold and stereoelectronic capacity of the coordinated auxiliary ligand are some of the associated selectivity factors in gold-catalyzed C-H bond functionalization reactions. Hence, in this review a comprehensive update about the action of different types of gold catalysts, from simple to sophisticated ones, on C-H bond reactions and their regiochemical outcome is disclosed. This review also highlights the catalytic applications of Au(I)- and Au(III)-species in creating new opportunities for the regio- and site-selective activation of challenging C-H bonds. Finally, it also intends to stress the potential applications in selective C-H bond activation associated with a variety of heterocycles recently described in the literature.

引用

页码：10495 / 10532

页数：38