Transgenerational epigenetic inheritance: from phenomena to molecular mechanisms

被引：46

作者：

Liberman, Noa ^{[1
,2
]}

Wang, Simon Yuan ^{[1
,2
]}

Greer, Eric Lieberman ^{[1
,2
]}

机构：

[1] Boston Childrens Hosp, Div Newborn Med, 300 Longwood Ave, Boston, MA 02115 USA

[2] Harvard Med Sch, Dept Pediat, Boston, MA 02115 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2019年 / 59卷

基金：

美国国家卫生研究院;

关键词：

CENTRAL-NERVOUS-SYSTEM; MATERNAL IMMUNE ACTIVATION; GUT MICROBIOTA COMPOSITION; HEMI-METHYLATED DNA; DE-NOVO METHYLATION; DOUBLE-STRANDED-RNA; CHAIN FATTY-ACIDS; PRION-LIKE FACTOR; CAENORHABDITIS-ELEGANS; DROSOPHILA-MELANOGASTER;

D O I：

10.1016/j.conb.2019.09.012

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Inherited information not encoded in the DNA sequence can regulate a variety of complex phenotypes. However, how this epigenetic information escapes the typical epigenetic erasure that occurs upon fertilization and how it regulates behavior is still unclear. Here we review recent examples of brain related transgenerational epigenetic inheritance and delineate potential molecular mechanisms that could regulate how non-genetic information could be transmitted.

引用

页码：189 / 206

页数：18

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