Influence of rheumatoid factor on the specificity of a rapid immunochromatographic test for diagnosing dengue infection

被引：22
作者：
Jelinek, T
Wastlhuber, J
Pröll, S
Schattenkirchner, M
Löscher, T
机构：
[1] Univ Munich, Dept Trop Med & Infect Dis, D-80802 Munich, Germany
[2] Univ Munich, Klinikum Innenstadt, Med Poliklin, Rheuma Einheit, Munich, Germany
来源：
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2000年 / 19卷 / 07期
关键词：
D O I：
10.1007/s100960000318
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
In order to determine the influence of rheumatoid factor in serum specimens on the specificity of an immunochromatographic test for the detection of antibodies against dengue virus, 50 clinical specimens containing rheumatoid factor were evaluated for cross reactivity with a commercially available assay. While specificity for the detection of immunoglobulin (Ig) G antibodies was 100%, the IgM component of the test showed false-positive results in 26% of cases. Thus, it is important to consider interference by rheumatoid factor when using immunochromatographic assays for the detection of specific IgM produced during dengue infection.
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收藏
页码：555 / 556
页数：2
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