Hypoglycemic and hypolipidemic effects of flavonoids from tatary buckwheat in type 2 diabetic rats.

Present study was designed to evaluate hypoglycemic and hypolipidemic effects of flavonoids from tatary buckwheat (TBF) in type 2 diabetic rats induced by combination of high-fat diet and streptozotocin injection. After induction of type 2 diabetes, diabetic rats were randomly divided into five groups: diabetic control group, low-dose TBF treated group, middle-dose TBF treated group, high -dose TBF treated group, and glibenclamide treated group, with normal rats used as the control group. After treatment for 28 days, body weight, fasting blood glucose (FBG), serum insulin, total cholesterol (TC), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), and low-density lipoprotein-cholesterol (LDL-C) levels were measured and oral glucose toler ance test (OGTT) was performed. The results showed that TBF significantly decreased FBG and serum insulin levels, increased body weights and improved glucose intolerance in diabetic rats. Furthermore, it decreased TC, TG, and LDL-C levels and increased HDL-C levels in these rats. These evidences indicated that TBF possesses hypoglycemic and hypolipidemic effects in type 2 diabetic rats and suggested that TBF has the potential to be a candidate for investigation as an anti-diabetic agent in humans.