A water-soluble pillar[5] arene as a new carrier for an old drug

被引：30
|
作者：
Barbera, Lucia [1 ]
Franco, Domenico [1 ]
De Plano, Laura M. [1 ]
Gattuso, Giuseppe [1 ]
Guglielmino, Salvatore P. P. [1 ]
Lentini, Germana [2 ]
Manganaro, Nadia [1 ]
Marino, Nino [3 ]
Pappalardo, Sebastiano [4 ]
Parisi, Melchiorre F. [1 ]
Puntoriero, Fausto [1 ]
Pisagatti, Ilenia [1 ]
Notti, Anna [1 ]
机构：
[1] Univ Messina, Dipartimento Sci Chim Biol Farmaceut & Ambientali, Viale F Stagno dAlcontres 31, I-98166 Messina, Italy
[2] Univ Messina, Dipartimento Med Clin & Sperimentale, Via Consolare Valeria 1, I-98125 Messina, Italy
[3] SAAD Ulster Univ, Sch Biomed Sci, Cromore Rd, Coleraine BT52 1SA, Londonderry, North Ireland
[4] Univ Catania, Dipartimento Sci Chim, Viale Andrea Doria 6, I-95125 Catania, Italy
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2017年 / 15卷 / 15期
关键词：
HOST-GUEST CHEMISTRY; SILICA NANOPARTICLES; BINDING; AMINOGLYCOSIDES; ENCAPSULATION; RECOGNITION; GENTAMICIN; RELEASE; ACID;
D O I：
10.1039/c7ob00530j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The remarkable affinity of deca-carboxylatopillar[5] arene WP5 towards the aminoglycoside antibiotic, amikacin, in aqueous media is reported; in vitro studies on Gram-positive bacteria (Staphylococcus aureus) show that drug entrapment inside WP5 also takes place in the presence of the microrganisms, thus pointing to WP5 as an appealing carrier for amikacin targeted delivery.
引用
收藏
页码：3192 / 3195
页数：4
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