Improved Stable Indocyanine Green (ICG)-Mediated Cancer Optotheranostics with Naturalized Hepatitis B Core Particles

被引：155

作者：

Shan, Wenjun ^{[1
]}

Chen, Ronghe ^{[2
,3
]}

Zhang, Qiang ^{[1
]}

Zhao, Jie ^{[1
]}

Chen, Binbin ^{[4
]}

Zhou, Xi ^{[1
]}

Ye, Shefang ^{[1
]}

Bi, Shengli ^{[5
]}

Nie, Liming ^{[2
,3
]}

Ren, Lei ^{[1
]}

机构：

[1] Xiamen Univ, Key Lab Biomed Engn Fujian Prov,Coll Mat, Fujian Collaborat Innovat Ctr Exploitat & Utiliza, Dept Biomat,State Key Lab Phys Chem Solid Surface, Xiamen 361005, Peoples R China

[2] Xiamen Univ, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diag, Xiamen 361102, Peoples R China

[3] Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, Xiamen 361102, Peoples R China

[4] Xiamen Univ, Coll Med, Xiamen 361102, Peoples R China

[5] Chinese Ctr Dis Control & Prevent, Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China

来源：

ADVANCED MATERIALS | 2018年 / 30卷 / 28期

基金：

中国国家自然科学基金;

关键词：

cancer optotheranostics; hepatitis B core protein virus-like particles; indocyanine green; multiple linear regression analysis; stability improvement; VIRUS-LIKE PARTICLES; PHOTODYNAMIC THERAPY; DRUG-DELIVERY; NANOPARTICLES; ENCAPSULATION; PHOTOTHERAPY; TEMPERATURE; STABILITY; EVOLUTION; TUMORS;

D O I：

10.1002/adma.201707567

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In recent years, hepatitis B core protein virus-like particle (HBc VLP) is an impressive biomaterial, which has attracted considerable attention due to favorable properties such as structural stability, high uptake efficiency, and biocompatibility in biomedical applications. Heretofore, only a few attempts have been made to apply it in physical, chemical, and biological therapy for cancer. In this study, a tumor-targeting RGD-HBc VLP is first fabricated through genetic engineering. For image-guided cancer phototherapy, indocyanine green (ICG) is loaded into RGD-HBc VLP via a disassembly/reassembly pathway and electrostatic attraction with high efficiency. The self-assembled stable RGD-HBc VLP significantly improves body retention (fourfold longer), aqueous stability, and target specificity of ICG. Remarkably, these positive reformations promote more accurate and sensitive imaging of U87MG tumor, as well as prolonged tumor destruction in comparison with free ICG. Moreover, the photothermal and photodynamic effect on tumors are quantitatively differentiated by multiple linear regression analysis. Overall, less-potent medicinal ICG can be perfectly rescued by bioengineered HBc VLP to realize enhanced cancer optotheranostics.

引用

页数：11

共 36 条

[1] Self-Assembled Peptide- and Protein-Based Nanomaterials for Antitumor Photodynamic and Photothermal Therapy [J].