Peptide-Based Strategies for Targeted Tumor Treatment and Imaging

被引：52

作者：

Ayo, Abiodun ^{[1
]}

Laakkonen, Pirjo ^{[1
,2
]}

机构：

[1] Univ Helsinki, Translat Canc Med Res Program, Fac Med, Helsinki 00014, Finland

[2] Univ Helsinki, HiLIFE Helsinki Inst Life Sci, Lab Anim Ctr, Helsinki 00014, Finland

来源：

PHARMACEUTICS | 2021年 / 13卷 / 04期

关键词：

tumor homing peptides; drug delivery; targeted delivery; BLOOD-BRAIN-BARRIER; NEWLY-DIAGNOSED GLIOBLASTOMA; CELL LUNG-CANCER; ERYTHROPOIETIC PROTOPORPHYRIA PATIENTS; STIMULATING HORMONE ANALOGS; AMINO-ACID TRANSPORTER; NECROSIS-FACTOR-ALPHA; RANDOMIZED PHASE-II; BREAST-CANCER; IN-VIVO;

D O I：

10.3390/pharmaceutics13040481

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cancer is one of the leading causes of death worldwide. The development of cancer-specific diagnostic agents and anticancer toxins would improve patient survival. The current and standard types of medical care for cancer patients, including surgery, radiotherapy, and chemotherapy, are not able to treat all cancers. A new treatment strategy utilizing tumor targeting peptides to selectively deliver drugs or applicable active agents to solid tumors is becoming a promising approach. In this review, we discuss the different tumor-homing peptides discovered through combinatorial library screening, as well as native active peptides. The different structure-function relationship data that have been used to improve the peptide's activity and conjugation strategies are highlighted.

引用

页数：31

共 308 条

[1] A backbone amide protecting group for overcoming difficult sequences and suppressing aspartimide formation [J].

Abdel-Aal, Abu-Baker M. ;

Papageorgiou, George ;

Raz, Richard ;

Quibell, Martin ;

Burlina, Fabienne ;

Offer, John .

JOURNAL OF PEPTIDE SCIENCE, 2016, 22 (05) :360-367

[2] Mass Spectrometry of Human Transporters [J].

Achour, Brahim ;

Al-Majdoub, Zubida M. ;

Rostami-Hodjegan, Amin ;

Barber, Jill .

ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 13, 2020, 13 :223-247

[3] De Novo Design of a Tumor-Penetrating Peptide [J].

Alberici, Luca ;

Roth, Lise ;

Sugahara, Kazuki N. ;

Agemy, Lilach ;

Kotamraju, Venkata R. ;

Teesalu, Tambet ;

Bordignon, Claudio ;

Traversari, Catia ;

Rizzardi, Gian-Paolo ;

Ruoslahti, Erkki .

CANCER RESEARCH, 2013, 73 (02) :804-812

[4] Liposomal drug delivery systems: From concept to clinical applications [J].

Allen, Theresa M. ;

Cullis, Pieter R. .

ADVANCED DRUG DELIVERY REVIEWS, 2013, 65 (01) :36-48

[5] DESIGN OF POTENT LINEAR ALPHA-MELANOTROPIN 4-10 ANALOGS MODIFIED IN POSITION-5 AND POSITION-10 [J].

ALOBEIDI, F ;

HRUBY, VJ ;

CASTRUCCI, AMD ;

HADLEY, ME .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (01) :174-179

[6] Uptake of a Cell Permeable G7-18NATE Construct Into Cells and Binding With the Grb7-SH2 Domain [J].

Ambaye, Nigus D. ;

Lim, Reece C. C. ;

Clayton, Daniel J. ;

Gunzburg, Menachem J. ;

Price, John T. ;

Pero, Stephanie C. ;

Krag, David N. ;

Wilce, Matthew C. J. ;

Aguilar, Marie-Isabel ;

Perlmutter, Patrick ;

Wilce, Jacqueline A. .

BIOPOLYMERS, 2011, 96 (02) :181-188

[7] Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies [J].

An, Zhenyi ;

Aksoy, Ozlem ;

Zheng, Tina ;

Fan, Qi-Wen ;

Weiss, William A. .

ONCOGENE, 2018, 37 (12) :1561-1575

[8] Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands [J].

Arap, MA ;

Lahdenranta, J ;

Mintz, PJ ;

Hajitou, A ;

Sarkis, AS ;

Arap, W ;

Pasqualini, R .

CANCER CELL, 2004, 6 (03) :275-284

[9] Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model [J].

Arap, W ;

Pasqualini, R ;

Ruoslahti, E .

SCIENCE, 1998, 279 (5349) :377-380

[10] CELL ATTACHMENT PROPERTIES OF COLLAGEN TYPE-VI AND ARG-GLY-ASP DEPENDENT BINDING TO ITS ALPHA-2(VI) AND ALPHA-3(VI) CHAINS [J].

AUMAILLEY, M ;

MANN, K ;

VONDERMARK, H ;

TIMPL, R .

EXPERIMENTAL CELL RESEARCH, 1989, 181 (02) :463-474

← 1 2 3 4 5 6 7 8 9 10 →