Health-Related Quality of Life in Patients With Locally Advanced Gastric Cancer Undergoing Perioperative or Postoperative Adjuvant S-1 Plus Oxaliplatin With D2 Gastrectomy: A Propensity Score-Matched Cohort Study

被引：2

作者：

Yu, Jianhong ^{[1
]}

Wang, Zaozao ^{[1
]}

Li, Zhexuan ^{[2
]}

Liu, Ying ^{[1
]}

Fan, Yingcong ^{[1
]}

Di, Jiabo ^{[1
]}

Cui, Ming ^{[1
]}

Xing, Jiadi ^{[1
]}

Zhang, Chenghai ^{[1
]}

Yang, Hong ^{[1
]}

Yao, Zhendan ^{[1
]}

Zhang, Nan ^{[1
]}

Chen, Lei ^{[1
]}

Liu, Maoxing ^{[1
]}

Xu, Kai ^{[1
]}

Tan, Fei ^{[1
]}

Gao, Pin ^{[1
]}

Su, Xiangqian ^{[1
]}

机构：

[1] Peking Univ Canc Hosp & Inst, Dept Gastrointestinal Surgery4, Key Lab Carcinogenesis & Translat Res, Beijing, Peoples R China

[2] Peking Univ Canc Hosp & Inst, Dept Canc Epidemiol, Key Lab Carcinogenesis & Translat Res, Beijing, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2022年 / 12卷

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

HRQOL; quality of life; gastric cancer; perioperative chemotherapy; SOX (S-1+oxaliplatin); BODY-MASS INDEX; DISTAL GASTRECTOMY; PHASE-III; CHINESE VERSION; GASTROESOPHAGEAL ADENOCARCINOMA; EUROPEAN-ORGANIZATION; EORTC QLQ-C30; OPEN-LABEL; CHEMOTHERAPY; VALIDATION;

D O I：

10.3389/fonc.2022.853337

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundSome high-quality clinical trials have proven the efficacy and safety of perioperative and postoperative S-1 with oxaliplatin (peri-SOX and post-SOX) for patients with locally advanced gastric cancer (LAGC) undergoing D2 gastrectomy. However, little is known about how health-related quality of life (HRQOL) changes over time in patients receiving peri-SOX or post-SOX chemotherapy. MethodsA prospective observational cohort (NCT04408859) identified 151 eligible patients with LAGC who underwent D2 gastrectomy with at least six cycles of peri-SOX or post-SOX chemotherapy from 2018 to 2020. HRQOL was assessed using the EROTC QLQ-C30 and its gastric module, QLQ-STO22, at indicated measurements, including the baseline, 1st, 3rd, 6th and 12th month after initiation of therapy. Baseline characteristics, therapeutic effects, and longitudinal HRQOL were compared between the peri-SOX and post-SOX groups after propensity score matching. HRQOL changes over time and the risk factors for scales with severe deterioration were further analyzed. ResultsNo statistically significant differences in longitudinal HRQOL were observed between patients in the peri-SOX and post-SOX groups, with comparable surgical outcomes and adverse chemotherapy events. Scales of social functioning, abnormal taste, and anxiety improved earlier in the peri-SOX group than in the post-SOX group. Score changes in both groups indicated that general deterioration and slower recovery usually occurred in the scales of physical, social, and role functioning, as well as symptoms of fatigue, reflux, diarrhea, and anxiety. ConclusionPeri-SOX showed a longitudinal HRQOL comparable to post-SOX in patients with LAGC who underwent D2 gastrectomy. The peri-SOX group had better performance in social functioning, abnormal taste, and anxiety at some measurements.

引用

页数：13

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