Small Cell Lung Cancer Derived from Adenocarcinoma with Mutant Epidermal Growth Factor Receptor Provides a Signature of Transcriptional Alteration in Tumor Cells

被引：13

作者：

Tenjin, Yuki ^{[1
,2
]}

Nakamura, Kazuyoshi ^{[1
]}

Ishizuka, Shiho ^{[1
]}

Saruwatari, Koichi ^{[1
]}

Sato, Ryo ^{[1
]}

Tomita, Yusuke ^{[1
]}

Saeki, Sho ^{[1
]}

Ichiyasu, Hidenori ^{[1
]}

Fujii, Kazuhiko ^{[1
]}

Ito, Takaaki ^{[2
]}

Sakagami, Takuro ^{[1
]}

机构：

[1] Kumamoto Univ, Fac Life Sci, Grad Sch Med Sci, Dept Resp Med, Kumamoto, Japan

[2] Kumamoto Univ, Fac Life Sci, Grad Sch Med Sci, Dept Pathol & Expt Med, Kumamoto, Japan

来源：

INTERNAL MEDICINE | 2019年 / 58卷 / 22期

关键词：

small cell lung cancer; epidermal growth factor receptor; adenocarcinoma; transcriptional alteration; acquired drug resistance; NEUROENDOCRINE DIFFERENTIATION; NOTCH; P53;

D O I：

10.2169/internalmedicine.2988-19

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Small cell lung cancer (SCLC) transformation of epidermal growth factor receptor (EGFR) mutant adenocarcinoma (ADC) during EGFR tyrosine kinase inhibitor (TKI) treatment is an example of a rare subset of acquired drug resistance. We herein report the case of a 75-year-old man treated with afatinib who was then diagnosed with SCLC transformation. After two years of successful treatment with afatinib, the tumor relapsed, and a re-biopsy revealed SCLC harboring EGFR exon 19 deletion. We encountered a case of transcriptional alteration, potentially important for SCLC transformation of EGFR mutant lung ADC, that was recognized via the expression of NOTCH, ASCL1 and RB1 on immunohistochemical staining.

引用

页码：3261 / 3265

页数：5

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