Autoimmune Hemolytic Anemia Accompanied by Reactivation of an Epstein-Barr Virus Infection with Suppressed CTL Response to EBV-infected Cells in an Elderly Man

被引：8

作者：

Arai, Ayako ^{[1
]}

Imadome, Ken-Ichi ^{[2
]}

Fujiwara, Shigeyoshi ^{[2
]}

Miura, Osamu ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Dept Hematol, Tokyo, Japan

[2] Natl Res Inst Child Hlth & Dev, Dept Infect Dis, Tokyo, Japan

来源：

INTERNAL MEDICINE | 2010年 / 49卷 / 04期

关键词：

autoimmune hemolytic anemia; Epstein-Barr virus; reactivation; enzyme-linked immunosorbent spot assay; LYMPHOPROLIFERATIVE DISORDER; HEMOPHAGOCYTIC SYNDROME; ANTI-I; APLASIA; LYMPHOMAS; PATIENT;

D O I：

10.2169/internalmedicine.49.2829

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An 88-year-old man with autoimmune hemolytic anemia (AIHA) who had been treated with low dose prednisolone developed a sudden worsening of his anemia accompanied by reactivation of Epstein-Barr virus (EBV). We established EBV-infected spontaneous lymphoblastoid cell lines (LCL), performed an enzyme-linked immunosorbent spot assay, and confirmed a significantly suppressed EBV-specific cytotoxic T-cell (CTL) response to the LCL. EBV reactivation might have been brought about by suppressed CTL activity which could have been due to low dose PSL administration or aging. Since the EBV-DNA titer decreased as AIHA improved, we concluded that EBV might have played a role in the development of anemia.

引用

页码：325 / 329

页数：5

共 18 条

[1] Pure red cell aplasia in a patient with trisomy X chromosome abnormality and reactivated Epstein-Barr virus infection [J].