IL-25-responsive, lineage-negative KLRG1hi cells are multipotential 'inflammatory' type 2 innate lymphoid cells

被引：513

作者：

Huang, Yuefeng ^{[1
]}

Guo, Liying ^{[1
]}

Qiu, Jin ^{[2
]}

Chen, Xi ^{[1
]}

Hu-Li, Jane ^{[1
]}

Siebenlist, Ulrich ^{[3
]}

Williamson, Peter R. ^{[2
]}

Urban, Joseph F. ^{[4
]}

Paul, William E. ^{[1
]}

机构：

[1] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA

[2] NIAID, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA

[3] NIAID, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

[4] ARS, Diet Genom & Immunol Lab, Beltsville Human Nutr Res Ctr, USDA, Beltsville, MD USA

来源：

NATURE IMMUNOLOGY | 2015年 / 16卷 / 02期

基金：

美国国家卫生研究院;

关键词：

TRANSCRIPTION FACTOR GATA3; T(H)2; POPULATION; ELICITS; IL-25; FATE;

D O I：

10.1038/ni.3078

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Innate lymphoid cells (ILCs) are lymphocyte-like cells that lack T cell or B cell antigen receptors and mediate protective and repair functions through cytokine secretion. Among these, type 2 ILCs (ILC2 cells) are able to produce type 2 cytokines. We report the existence of an inflammatory ILC2 (iILC2) population responsive to interleukin 25 (IL-25) that complemented IL-33-responsive natural ILC2 (nILC2) cells. iILC2 cells developed into nILC2-like cells in vitro and in vivo and contributed to the expulsion of Nippostrongylus brasiliensis. They also acquired IL-17-producing ability and provided partial protection against Candida albicans. We propose that iILC2 cells are transient progenitors of ILCs mobilized by inflammation and infection that develop into nILC2-like cells or ILC3-like cells and contribute to immunity to both helminths and fungi.

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页码：161 / +

页数：10

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