Mechanisms and consequences of entosis

被引：80

作者：

Krishna, Shefali ^{[1
,2
]}

Overholtzer, Michael ^{[1
,2
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10065 USA

[2] Mem Sloan Kettering Canc Ctr, Louis V Gerstner Jr Grad Sch Biomed Sci, New York, NY 10065 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2016年 / 73卷 / 11-12期

关键词：

Entosis; Entotic cell death; Cannibalism; Cell-in-cell; Engulfment; Phagocytosis; Autophagy; LAP; Cell competition; Aneuploidy; CELL-IN-CELL; BCL-2; FAMILY-MEMBERS; DICTYOSTELIUM-DISCOIDEUM; DEATH PROCESS; HUMAN CANCERS; HOST-DEFENSE; CANNIBALISM; COMPETITION; AUTOPHAGY; BAX;

D O I：

10.1007/s00018-016-2207-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Multiple mechanisms have emerged where the engulfment of whole live cells, leading to the formation of what are called 'cell-in-cell' structures, induces cell death. Entosis is one such mechanism that drives cell-in-cell formation during carcinogenesis and development. Curiously, entotic cells participate actively in their own engulfment, by invading into their hosts, and are then killed non-cell-autonomously. Here we review the mechanisms of entosis and entotic cell death and the consequences of entosis on cell populations.

引用

页码：2379 / 2386

页数：8

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