Mechanism of glutamate mutase: Identification and kinetic competence of acrylate and glycyl radical as intermediates in the rearrangement of glutamate to methylaspartate

被引：40

作者：

Chih, HW ^{[1
]}

Marsh, ENG ^{[1
]}

机构：

[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2000年 / 122卷 / 43期

关键词：

D O I：

10.1021/ja002488+

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：10732 / 10733

页数：2

共 27 条

[1] MODEL EXPERIMENTS PERTAINING TO THE MECHANISM OF ACTION OF VITAMIN-B12-DEPENDENT ALPHA-METHYLENEGLUTARATE MUTASE [J].

ASHWELL, S ;

DAVIES, AG ;

GOLDING, BT ;

HAYMOTHERWELL, R ;

MWESIGYEKIBENDE, S .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1989, (19) :1483-1485

[2] The Yin-Yang of cobalamin biochemistry [J].

Banerjee, R .

CHEMISTRY & BIOLOGY, 1997, 4 (03) :175-186

[3] CLONING, SEQUENCING AND EXPRESSION OF THE GENE ENCODING THE COENZYME B-12-DEPENDENT 2-METHYLENEGLUTARATE MUTASE FROM CLOSTRIDIUM-BARKERI IN ESCHERICHIA-COLI [J].

BEATRIX, B ;

ZELDER, O ;

LINDER, D ;

BUCKEL, W .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1994, 221 (01) :101-109

[4]

Becker A, 1999, NAT STRUCT BIOL, V6, P969

[5] Identification of the 4-glutamyl radical as an intermediate in the carbon skeleton rearrangement catalyzed by coenzyme B12-dependent glutamate mutase from Clostridium cochlearium [J].

Bothe, H ;

Darley, DJ ;

Albracht, SPJ ;

Gerfen, GJ ;

Golding, BT ;

Buckel, W .

BIOCHEMISTRY, 1998, 37 (12) :4105-4113

[6]

BUCKEL W, 1996, CHEM SOC REV, P329

[7] Adenosylcobalamin-dependent glutamate mutase: Examination of substrate and coenzyme binding in an engineered fusion protein possessing simplified subunit structure and kinetic properties [J].

Chen, HP ;

Marsh, ENG .

BIOCHEMISTRY, 1997, 36 (48) :14939-14945

[8] Pre-steady-state kinetic investigation of intermediates in the reaction catalyzed by adenosylcobalamin-dependent glutamate mutase [J].

Chih, HW ;

Marsh, ENG .

BIOCHEMISTRY, 1999, 38 (41) :13684-13691

[9] A MODEL FOR THE ENZYME-CATALYZED, COENZYME-B12-DEPENDENT INTERCONVERSION OF BETA-METHYLASPARTATE WITH GLUTAMATE [J].

DOWD, P ;

CHOI, SC ;

DUAH, F ;

KAUFMAN, C .

TETRAHEDRON, 1988, 44 (08) :2137-2148

[10]

GOLDING BT, 1986, ADENOSYLCOBALAMIN DE, P404

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