Correlation between Serum RANTES Levels and the Severity of Parkinson's Disease

被引：58

作者：

Tang, Peng ^{[1
]}

Chong, Li ^{[1
]}

Li, Xiaoqing ^{[1
]}

Liu, Yue ^{[1
]}

Liu, Peng ^{[1
]}

Hou, Chen ^{[1
]}

Li, Rui ^{[1
]}

机构：

[1] Shaanxi Prov Peoples Hosp, Dept Geriatr Neurol, Xian 710068, Peoples R China

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2014年 / 2014卷

基金：

中国国家自然科学基金;

关键词：

CENTRAL-NERVOUS-SYSTEM; CHEMOKINE; RECEPTORS;

D O I：

10.1155/2014/208408

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Inflammatory mediators may reflect a role of systemic inflammation in the neurodegenerative process of Parkinson's disease (PD). Interleukin-6 (IL-6) and chemokine ligand 5 (CCL5), also known as RANTES (regulated on activation, normal T cell expressed and secreted), have been implicated in neurodegenerative diseases including PD. Serum levels of RANTES and IL-6 of 78 consecutive PD patients and age-matched 80 controls were measured. Patients with PD had higher RANTES and IL-6 levels compared with the controls. We found that serumR ANTES levels strongly correlated with Hoehn-Yahr score and disease duration in PD patients. This study indicated that patients with PD have an on-going systemic inflammatory profile where the elevated peripheral production of RANTES may play a role in the neurodegenerative process.

引用

页码：1 / 4

页数：4

共 21 条

[1] Neuronal damage in brain inflammation [J].

Aktas, Orhan ;

Ullrich, Oliver ;

Infante-Duarte, Carmen ;

Nitsch, Robert ;

Zipp, Frauke .

ARCHIVES OF NEUROLOGY, 2007, 64 (02) :185-189

[2] Internalization of IgG-Coated Targets Results in Activation and Secretion of Soluble CD40 Ligand and RANTES by Human Platelets [J].

Antczak, Adam J. ;

Vieth, Joshua A. ;

Singh, Navinderjit ;

Worth, Randall G. .

CLINICAL AND VACCINE IMMUNOLOGY, 2011, 18 (02) :210-216

[3] RANTES: a versatile and controversial chemokine [J].

Appay, V ;

Rowland-Jones, SL .

TRENDS IN IMMUNOLOGY, 2001, 22 (02) :83-87

[4] Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases [J].

Cartier, L ;

Hartley, O ;

Dubois-Dauphin, M ;

Krause, KH .

BRAIN RESEARCH REVIEWS, 2005, 48 (01) :16-42

[5] Peripheral inflammatory biomarkers and risk of Parkinson's disease [J].

Chen, Honglei ;

O'Reilly, Eilis J. ;

Schwarzschild, Michael A. ;

Ascherio, Alberto .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2008, 167 (01) :90-95

[6] The role of neuroinflammation on the pathogenesis of Parkinson's disease [J].

Chung, Young Cheul ;

Ko, Hyuk Wan ;

Bok, Eugene ;

Park, Eun Soo ;

Huh, Sue Hee ;

Nam, Jin Han ;

Jin, Byung Kwan .

BMB REPORTS, 2010, 43 (04) :225-232

[7] Human platelet antigen-1a antibodies induce the release of the chemokine RANTES from human platelets [J].

Dettke, M ;

Dreer, M ;

Höcker, P ;

Panzer, S .

VOX SANGUINIS, 2001, 81 (03) :199-203

[8] Parkinson disease with old-age onset - A comparative study with subjects with middle-age onset [J].

Diederich, NJ ;

Moore, CG ;

Leurgans, SE ;

Chmura, TA ;

Goetz, CG .

ARCHIVES OF NEUROLOGY, 2003, 60 (04) :529-533

[9] Intrathecal chemokine synthesis in mild cognitive impairment and Alzheimer disease [J].

Galimberti, D ;

Schoonenboom, N ;

Scheltens, P ;

Fenoglio, C ;

Bouwman, F ;

Venturelli, E ;

Guidi, I ;

Blankenstein, MA ;

Bresolin, N ;

Scarpini, E .

ARCHIVES OF NEUROLOGY, 2006, 63 (04) :538-543

[10] Interleukin-6 Serum Levels in Patients with Parkinson's Disease [J].

Hofmann, Kerly Wollmeister ;

Schumacher Schuh, Artur Francisco ;

Saute, Jonas ;

Townsend, Raquel ;

Fricke, Daniele ;

Leke, Renata ;

Souza, Diogo O. ;

Portela, Luis Valmor ;

Fagundes Chaves, Marcia Lorena ;

Rieder, Carlos R. M. .

NEUROCHEMICAL RESEARCH, 2009, 34 (08) :1401-1404

← 1 2 3 →