The FAGenomicH project: towards a whole candidate gene approach to identify markers associated with fatness and production traits in pigs and investigate the pig as a model for human obesity

被引：0

作者：

Fontanesi, Luca ^{[1
]}

Fronza, Raffaele ^{[2
]}

Scotti, Emilio

Colombo, Michela

Speroni, Camilla

Tognazzi, Lucia

Galimberti, Giuliano ^{[3
]}

Calo, Daniela Giovanna ^{[3
]}

Bonora, Elena ^{[4
]}

Vargiolu, Manuela ^{[4
]}

Romeo, Giovanni ^{[4
]}

Casadio, Rita ^{[2
]}

Russo, Vincenzo

机构：

[1] Univ Bologna, DIPROVAL, Sez Allevamenti Zootecn, Fac Agr, I-42100 Reggio Emilia, Italy

[2] Univ Bologna, Biocomp Grp, Dipartimento Biol Evoluzionist Sperimentale, I-40126 Bologna, Italy

[3] Univ Bologna, Dipartimento Sci Stat Paolo Fortunati, I-40126 Bologna, Italy

[4] Univ Bologna, Dipartimento Salute Donna Bambino & Adolescente, Unita Operat Genet Med, Policlin S Orsola Malpighi, I-40126 Bologna, Italy

来源：

ITALIAN JOURNAL OF ANIMAL SCIENCE | 2009年 / 8卷

关键词：

Pig; Fatness; Obesity; Candidate genes; RISK;

D O I：

10.4081/ijas.2009.s2.87

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Fatness in pigs is a complex trait for which a large number of genes are expected to be involved. Genetics of human obesity could take advantages from genetic information coming from the pig and vice versa. To these aims, a comprehensive candidate gene approach could be helpful. We catalogued all genes affecting fatness on both species, and identified in silico and by resequencing porcine SNPs on a large number of candidate genes. In addition, we applied a selective genotyping approach to identify markers associated with fat deposition in pigs. This approach was tested genotyping the IGF2 intron3-g.3072G>A mutation and novel markers in the PCSK1 and TBC1D1 genes. Polymorphisms in these genes resulted associated with back fat thickness in Italian Large White pigs.

引用

页码：87 / 89

页数：3