Prognostic significance of lymphocyte-to-monocyte ratio in diffuse large B-cell lymphoma: a systematic review and meta-analysis

被引：10
作者：
Xia, Wen-Kai [1 ]
Lin, Qing-Feng [2 ]
Shen, Dong [2 ]
Liu, Zhi-Li [2 ]
Su, Jun [2 ]
Mao, Wei-Dong [2 ]
机构：
[1] Southeast Univ, Affiliated Jiangyin Hosp, Dept Nephrol, Coll Med, Jiangyin 214400, Jiangsu, Peoples R China
[2] Southeast Univ, Affiliated Jiangyin Hosp, Dept Oncol, Coll Med, 163 Shoushan Rd, Jiangyin 214400, Jiangsu, Peoples R China
来源：
FEBS OPEN BIO | 2016年 / 6卷 / 06期
关键词：
diffuse large B-cell lymphoma; lymphocyte-to-monocyte ratio; meta-analysis; prognosis; ABSOLUTE LYMPHOCYTE; RITUXIMAB; COUNT; SURVIVAL; IMPACT; SCORE; DIAGNOSIS; IPI;
D O I：
10.1002/2211-5463.12066
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Published evidence on the prognostic significance of lymphocyte-to-monocyte ratio (LMR) in diffuse large B-cell lymphoma (DLBCL) is controversial. We performed an updated meta-analysis from 12 reports with 5021 patients to more accurately evaluate the prognostic value of LMR in DLBCL. Herein, we confirmed that patients with low LMR had shorter overall survival and progression-free survival than those with high LMR in DLBCL. Subgroup analyses indicated that patient source, cut-off values of LMR, treatment methods, and sample size showed similar prognostic performance in DLBCL patients. No significant heterogeneity was observed for progression-free survival (PFS, P-het = 0.192) among the enrolled studies. The meta-analysis suggests that the LMR may be a potential biomarker in the prediction of clinical outcomes for DLBCL patients.
引用
收藏
页码：558 / 565
页数：8
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