YieJ (CbrC) Mediates CreBC-Dependent Colicin E2 Tolerance in Escherichia coli

被引：17

作者：

Cariss, S. James L.

Constantinidou, Chrystala ^{[2
]}

Patel, Mala D. ^{[2
]}

Takebayashi, Yuiko

Hobman, Jon L. ^{[2
]}

Penn, Charles W. ^{[2
]}

Avison, Matthew B. ^{[1
]}

机构：

[1] Univ Bristol, Dept Cellular & Mol Med, Sch Med Sci, Bristol BS8 1TD, Avon, England

[2] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England

来源：

JOURNAL OF BACTERIOLOGY | 2010年 / 192卷 / 13期

基金：

英国生物技术与生命科学研究理事会;

关键词：

GENE-EXPRESSION; BETA-LACTAMASES; K-12; REGULATOR; MUTANTS; PROTEIN; GENOME; GROWTH; MUTATIONS; PHENOTYPE;

D O I：

10.1128/JB.01352-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Colicin E2-tolerant (known as Cet2) Escherichia coli K-12 mutants overproduce an inner membrane protein, CreD, which is believed to cause the Cet2 phenotype. Here, we show that overproduction of CreD in a Cet2 strain results from hyperactivation of the CreBC two-component regulator, but CreD overproduction is not responsible for the Cet2 phenotype. Through microarray analysis and gene knockout and overexpression studies, we show that overexpression of another CreBC-regulated gene, yieJ (also known as cbrC), causes the Cet2 phenotype.

引用

收藏

页码：3329 / 3336

页数：8

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