A neuro-stimulus chip with telemetry unit for retinal prosthetic device

被引:281
作者
Liu, WT [1 ]
Vichienchom, K
Clements, M
DeMarco, SC
Hughes, C
McGucken, E
Humayun, MS
de Juan, E
Weiland, JD
Greenberg, R
机构
[1] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA
[2] Johns Hopkins Univ, Wilmer Ophthalmol Inst, Baltimore, MD 21287 USA
基金
美国国家科学基金会;
关键词
biomedical telemetry; neuro-stimulator; retinal prosthesis;
D O I
10.1109/4.871327
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
In this retinal prosthesis project, a rehabilitative device is designed to replace the functionality of defective photoreceptors in patients suffering from retinitis pigmentosa (RP) and age-related macular degeneration (AMD), The device consists of an extraocular and an intraocular unit. The implantable component receives power and a data signal via a telemetric inductive link between the two units. The extraocular unit includes a video camera and video processing board, a telemetry protocol encoder chip, and an RF amplifier and primary coil. The intraocular unit consists of a secondary coil, a rectifier and regulator, a retinal chip with a telemetry protocol decoder, a stimulus signal generator, and an electrode array, This paper focuses on the design, fabrication, and testing of a microchip which serves as the telemetry protocol decoder and stimulus signal generator. It is fabricated by MOSIS with 1.2-mm CMOS technology and was demonstrated to provide the desired biphasic current stimulus pulses for an array of 100 retinal electrodes at video frame fates.
引用
收藏
页码:1487 / 1497
页数:11
相关论文
共 22 条
[1]  
BOUVIER J, 1997, IEEE INT SOL STAT CI, P296
[2]  
CHOW A, 1997, NEUROSCI LETT, P13
[3]   ANALYSIS OF RESONANT COUPLED COILS IN THE DESIGN OF RADIO-FREQUENCY TRANS-CUTANEOUS LINKS [J].
DONALDSON, ND ;
PERKINS, TA .
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 1983, 21 (05) :612-627
[4]   Learning retina implants with epiretinal contacts [J].
Eckmiller, R .
OPHTHALMIC RESEARCH, 1997, 29 (05) :281-289
[5]   MUTUAL INDUCTANCE OF AIR-CORED COILS - EFFECT ON DESIGN OF RADIO-FREQUENCY COUPLED IMPLANTS [J].
FLACK, FC ;
JAMES, ED ;
SCHLAPP, DM .
MEDICAL & BIOLOGICAL ENGINEERING, 1971, 9 (02) :79-&
[6]  
Gray P. R., 1993, ANAL DESIGN ANALOG I
[7]  
GREENBERG R, 1998, THESIS J HOPKINS U B
[8]   Pattern electrical stimulation of the human retina [J].
Humayun, MS ;
de Juan, E ;
Weiland, JD ;
Dagnelie, G ;
Katona, S ;
Greenberg, R ;
Suzuki, S .
VISION RESEARCH, 1999, 39 (15) :2569-2576
[9]   Visual perception elicited by electrical stimulation of retina in blind humans [J].
Humayun, MS ;
deJuan, E ;
Dagnelie, G ;
Greenberg, RJ ;
Prost, RH ;
Phillips, DH .
ARCHIVES OF OPHTHALMOLOGY, 1996, 114 (01) :40-46
[10]  
Johns D.A., 2008, Analog integrated circuit design