African origin of GB virus C hepatitis G virus

被引：29

作者：

Tanaka, Y

Mizokami, M ^{[1
]}

Orito, E

Ohba, K

Kato, T

Kondo, Y

Mboudjeka, I

Zekeng, L

Kaptue, L

Bikandou, B

M'Pele, P

Takehisa, J

Hayami, M

Suzuki, Y

Gojobori, T

机构：

[1] Nagoya City Univ, Sch Med, Dept Med 2, Mizuho Ku, Nagoya, Aichi 467, Japan

[2] CHU Yaounde, Lab Hematol & Immunol, Yaounde, Cameroon

[3] Lab Natl Sante Publ, Brazzaville, Rep Congo

[4] Kyoto Univ, Inst Virus Res, Kyoto 606, Japan

[5] Natl Inst Genet, Ctr Informat Biol, Mishima, Shizuoka 411, Japan

来源：

FEBS LETTERS | 1998年 / 423卷 / 02期

关键词：

GB virus C; hepatitis G virus; Africa; Pygmy; indel; NS5A; phylogenetic analysis;

D O I：

10.1016/S0014-5793(98)00083-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ninety-four GB virus C/hepatitis G virus (GBV-C/HGV) RNA-positive serum samples were obtained from all over the world, We found that all 15 GBV-C/HGV isolates from the Pygmies and the Bantu in the Central African region had a 12-amino acid indel (i.e. insertion or deletion) in the non-structural protein (NS) 5A region, Phylogenetic analyses of the NS5A region, using GBV-A as an outgroup, showed that these 15 isolates had diverged from the common ancestor much earlier than the remaining isolates, indicating an African origin of GBVC/HGV. (C) 1998 Federation of European Biochemical Societies.

引用

页码：143 / 148

页数：6

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