African origin of GB virus C hepatitis G virus

被引：29
作者：
Tanaka, Y
Mizokami, M [1 ]
Orito, E
Ohba, K
Kato, T
Kondo, Y
Mboudjeka, I
Zekeng, L
Kaptue, L
Bikandou, B
M'Pele, P
Takehisa, J
Hayami, M
Suzuki, Y
Gojobori, T
机构：
[1] Nagoya City Univ, Sch Med, Dept Med 2, Mizuho Ku, Nagoya, Aichi 467, Japan
[2] CHU Yaounde, Lab Hematol & Immunol, Yaounde, Cameroon
[3] Lab Natl Sante Publ, Brazzaville, Rep Congo
[4] Kyoto Univ, Inst Virus Res, Kyoto 606, Japan
[5] Natl Inst Genet, Ctr Informat Biol, Mishima, Shizuoka 411, Japan
来源：
FEBS LETTERS | 1998年 / 423卷 / 02期
关键词：
GB virus C; hepatitis G virus; Africa; Pygmy; indel; NS5A; phylogenetic analysis;
D O I：
10.1016/S0014-5793(98)00083-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ninety-four GB virus C/hepatitis G virus (GBV-C/HGV) RNA-positive serum samples were obtained from all over the world, We found that all 15 GBV-C/HGV isolates from the Pygmies and the Bantu in the Central African region had a 12-amino acid indel (i.e. insertion or deletion) in the non-structural protein (NS) 5A region, Phylogenetic analyses of the NS5A region, using GBV-A as an outgroup, showed that these 15 isolates had diverged from the common ancestor much earlier than the remaining isolates, indicating an African origin of GBVC/HGV. (C) 1998 Federation of European Biochemical Societies.
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收藏
页码：143 / 148
页数：6
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