Synthesis and anti-inflammatory evaluation of novel paclitaxel analogs

被引：2

作者：

Xu, Pei-Pei ^{[1
]}

Li, Qing-Feng ^{[1
]}

Cui, Yong-Mei ^{[1
]}

Lin, Hai-Xia ^{[1
]}

机构：

[1] Shanghai Univ, Coll Sci, Innovat Drug Res Ctr, Dept Chem, Shanghai 200444, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2017年 / 19卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Paclitaxel; anti-inflammatory; tumor necrosis factor; lipopolysaccharide; NECROSIS-FACTOR PRODUCTION; MURINE MACROPHAGES; NITRIC-OXIDE; STRUCTURAL SIGNIFICANCE; TAXOIDS; POSITION; AGENTS; CELLS;

D O I：

10.1080/10286020.2016.1236793

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A series of paclitaxel analogs modified at C-3-N and C-7 positions were synthesized from baccatin III and their structures were confirmed by H-1-NMR, C-13-NMR, HR-MS. Compound 7e exhibited potent ability to decrease TNF (tumor necrosis factor ) in the LPS-activated RAW264.7 murine macrophage-like cell line. The preliminary data indicated that the anti-inflammatory effects may be related to MD-2 and Toll-like receptor 4 (TLR4), rather than Toll-like receptor 2 (TLR2).

引用

页码：803 / 822

页数：20

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